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MetabolomicsNon-invasive urinary metabolomic profiles discriminate biliary atresia from infantile hepatitis syndrome
INTRODUCTION: Neonatal cholestatic disorders are a group of hepatobiliary diseases occurring in the first 3 months of life. The most common causes of neonatal cholestasis are infantile hepatitis syndrome (IHS) and biliary atresia (BA). The clinical manifestations of the two diseases are ...
2019-06-25 | MTBLS689 | MetaboLights
MetabolomicsIntegrated Multi-omics Analysis of Human Biliary Organoids Reveals Dysregulated Metabolic and Fibro-Inflammatory Programs in Biliary Atresia
Human intrahepatic biliary organoids were established from liver tissues of children with BA (n = 11), choledochal cysts (CC, n = 5), and histologically normal controls (NC, n = 5). We performed comprehensive multi-omics profiling, including transcriptomics, proteomics, phosphoproteomics, and untarg...
2026-09-02 | MTBLS15528 | MetaboLights
TranscriptomicsComprehensive gene expression profile of human livers from patients with biliary atresia at the time of diagnosis and the corresponding disease and normal controls
Liver biopsy samples were obtained from 64 infants with biliary atresia at the time of intraoperative cholangiogram. Liver biopsy samples were obtained from 14 age-matched infants with other causes of intrahepatic cholestasis, and from 7 deceased-donor children. GeneChip® Human Gene 1.0 ST Array (Af...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-46960 | biostudies-arrayexpress
TranscriptomicsStaging of biliary atresia at diagnosis by molecular profiling of the liver
BACKGROUND: Young age at portoenterostomy has been linked to improved outcome in biliary atresia, but pre-existing biological factors may influence the rate of disease progression. In this study, we aimed to determine whether molecular profiling of the liver identifies stages of disease at diagnosis...
ORGANISM(S): Homo sapiens 
2010-08-31 | E-GEOD-15235 | biostudies-arrayexpress
ProteomicsHuman stool proteome analysis from patients with biliary atresia
Stool samples from four patients with Biliary atresia (BA) and three patients with neonatal cholestasis of other etiologies (non-BA) were analyzed by overlapping DIA-MS.
ORGANISM(S): Homo Sapiens (human) 
2021-11-06 | PXD022391 | JPOST Repository
TranscriptomicsHepatic gene expression during the development of experimental biliary atresia in different mouse strains
Biliary atresia (BA) is a rare cholestatic disease of unknown etiology that affects infants and shows an incidence of 1 out of 18,000 live births in Europe (1). The first therapeutic option is a timely performed portoenterostomy. However, the majority of patients suffer from a progressive inflammato...
ORGANISM(S): Mus musculus 
2009-08-30 | E-GEOD-13245 | biostudies-arrayexpress
ProteomicsQuantitative LC-MS/MS Proteomics of paediatric biliary atresia human liver microsomes
We report label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases and nucleases in 25 human liver microsomal samples, taken from patients with biliary atresia. Nearly 3500 proteins were identified and quantified. These data can be used in physiolog...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020974 | Pride
Human Quantitative proteomics Biliary atresia Paediatric livers Lc-ms/ms 
ProteomicsIntegrative analysis of proteomic and phosphoproteomic of granulosa cells during follicular atresia in porcine
Ovarian follicular atresia is a natural physiological process, but its mechanism is not fully understood. In this study, a quantitative proteomic and phosphoproteomic of granulosa cell (GC) in the healthy (H), slightly atretic (SA), and atretic follicles (A) of porcine were performed by TMT labeling...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-09-09 | PXD020899 | Pride
Porcine  follicular atresia  granulosa cell  proteomic  phosphoproteomic 
ProteomicsProteomics defines plasma biomarkers for the early diagnosis of biliary atresia
Early diagnosis of biliary atresia (BA) is crucial for improving the chances of survival and preserving the liver function of children with BA. To explore potential biomarkers for early diagnosis of BA with other non-BA jaundice cases, we performed proteomic analysis with data-independent acquisitio...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048938 | Pride
Machine learning Biliary atresia Dia Prm Plasma Cholestasis 
TranscriptomicsOogenesis in Solea senegalensis: vitellogenic versus atretic ovaries
Transcriptional profile changes in ovary during the reproductive cycle of Solea senegalensis: from vitellogenic stage to atresia stage obtained at different times during the annual reproductive cycle. An oligo microarray based on ESTs sequenced from S. senegalensis previously designed (Cerdà et al....
ORGANISM(S): Solea senegalensis 
2010-06-21 | E-GEOD-17334 | biostudies-arrayexpress
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