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ProteomicsAtxn2-Knock-Out mice show branched chain amino acids and fatty acids pathway alterations
Human Ataxin-2 (ATXN2) gene locus variants have been associated with obesity, diabetes mellitus type 1 and hypertension in genome-wide association studies, while mouse studies showed the knock-out of Atxn2 to lead to obesity, insulin resistance and dyslipidemia. Intriguingly, the deficiency of ATXN2...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-07 | MSV000084933 | MassIVE
TranscriptomicsRNA-seq of Spinocerebellar Ataxia Type2 (SCA2) transgenic mouse lines and age-matched wild-type
Spinocerebellar ataxia type 2 (SCA2) is among the progressive neurodegenerative polyglutamine (polyQ) diseases. It is caused by a CAG repeat expansion in an encoded region of the ATXN2 gene giving rise to an expanded polyQ domain in the encoded ATXN2 protein. SCA2 is an autosomal dominant disorder c...
ORGANISM(S): Mus musculus 
2017-12-09 | E-MTAB-6293 | biostudies-arrayexpress
ProteomicsAtxn2-Knock-Out mice show branched chain amino acids and fatty acids pathway alterations
Human Ataxin-2 (ATXN2) gene locus variants have been associated with obesity, diabetes mellitus type 1 and hypertension in genome-wide association studies, while mouse studies showed the knock-out of Atxn2 to lead to obesity, insulin resistance and dyslipidemia. Intriguingly, the deficiency of ATXN2...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-08 | PXD003155 | Pride
Spinocerebellar ataxia type 2 (atxn2)  mass spectrometry  proteome profiling  metabolome profiling  multiple reaction monitoring (mrm)  protein - protein interaction network (ppi) analysis  pathway analysis. 
GenomicsThe RNA-binding protein ATXN2 controls cellular processes during megakaryopoiesis.
The RNA-binding protein ATXN2 controls cellular processes during megakaryopoiesis.
PRJNA543224 | ENA
TranscriptomicsATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice
Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)31. This is thought to mediate toxic gain-of-function by protein aggregation, and affect RNA processing, resulting in degenerative processes affecting preferenti...
ORGANISM(S): Mus musculus 
2012-07-24 | E-GEOD-39640 | biostudies-arrayexpress
GenomicsThe TENT5A–ATXN2 axis modulates cellular survival during heat stress.
The TENT5A–ATXN2 axis modulates cellular survival during heat stress.
PRJNA1369545 | ENA
ProteomicsThe RNA-binding protein ATXN2 controls cellular processes during megakaryopoiesis
Megakaryocytes accumulate mRNA during their maturation, which is required for the correct spatio-temporal production of cytoskeletal proteins, membranes and platelet-specific granules, and for the subsequent shedding of thousands of platelets per cell. Gene expression profiling identified the RNA bi...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD015823 | Pride
Lc-ms Megakaryopoiesis 
TranscriptomicsThe TENT5A–ATXN2 axis modulates cellular survival during heat stress.
Stress conditions elicit the formation of different kinds of stress granules. The assembly and composition of heat-induced stress granules remain poorly characterized. Here, we show that the cytoplasmic RNA polyadenylases TENT5A regulate the formation and function of ATXN2-positive heat-induced stre...
ORGANISM(S): Mus musculus 
2026-07-10 | GSE311487 | GEO
TranscriptomicsThe RNA-binding protein ATXN2 controls cellular processes during megakaryopoiesis.
Megakaryocytes accumulate mRNA during their maturation, which is required for the correct spatio-temporal production of cytoskeletal proteins, membranes and platelet-specific granules, and for the subsequent shedding of thousands of platelets per cell. Gene expression profiling identified the RNA bi...
ORGANISM(S): Homo sapiens 
2020-02-14 | GSE131308 | GEO
UnknownETS1 regulates the expression of ATXN2.
Not available
S-EPMC3490512 | biostudies-literature
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