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ProteomicsAurora B opposes PP1 function in mitosis through phosphorylation of the conserved RVxF binding motif in PP1 regulatory proteins
Protein phosphatase 1 (PP1) is a highly conserved protein phosphatase that opposes the actions of a diverse set of Ser-Thr protein kinases by controlling the majority of serine-threonine (Ser-Thr) dephosphorylation reactions in eukaryotes. PP1 gains substrate specificity through binding to a large n...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-03-30 | MSV000082226 | MassIVE
TranscriptomicsThe investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell cycle progression in mouse bladder cancer cells in vitro and in vivo
PURPOSE: Despite over 70,000 new cases of bladder cancer in the United States annually, patients with advanced disease have a poor prognosis due to limited treatment modalities. We evaluate the role of Aurora A, identified as an upregulated candidate molecule in bladder cancer, in regulating bladde...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-42089 | biostudies-arrayexpress
ProteomicsThe structural basis of the multi-step allosteric activation of Aurora B kinase
Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not clear how these phosphorylations activate the ...
ORGANISM(S): Xenopus cf. laevis UF 185698 
2023-05-31 | PXD038935 | Pride
Xenopus laevis Hdx-ms Aurora b 
ProteomicsAurora B kinase disrupts the extended conformation of lattice-bound Kinesin-13 MCAK
We reveal that MCAK has a compact conformation in solution using cross-linking and electron microscopy. When MCAK is bound to the microtubule ends, it adopts an extended conformation with the N terminus and neck region of MCAK interacting with the microtubule. Also Aurora Bphosphorylation does not a...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD008215 | Pride
Mcak Phosphorylation Microtubules Aurora b 
Proteomicspre-mRNA splicing is regulated by an Aurora-A-mediated phopsho-signaling network
In this study, we identified many new potential interactors of the Aurora-A kinase using a proteomic approach. A significant portion of Aurora-A interaction network is composed of proteins involved in pre-mRNA splicing, implying that Aurora-A signaling extends beyond its canonical function. Aurora-A...
ORGANISM(S): Homo sapiens (Human) 
2024-12-11 | PXD021093 | Pride
Aurora kinase Lc-ms/ms 
GenomicsThe Aurora B kinase and the polycomb protein Ring1B combine to regulate active promoters in quiescent lymphocytes [ChIP-seq]
Genome-wide distribution of proteins and histone marks in CD43 negative mouse resting B cells ChIP-seq analyses of Aurora B, Ring1B, Bcx7, USP16, H3K27me3, and Ezh2 were carried out on wild-typeCD43 negative resting B cells. ChIP-seq datasets obtained from Aurora B knockout and RingiB knockout cel...
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-42705 | biostudies-arrayexpress
ProteomicsAurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics.
Precise regulation of kinetochore-microtubules is essential for successful chromosome segregation. Central to this regulation is Aurora B kinase, which phosphorylates kinetochore substrates to promote microtubule turnover. A critical target of Aurora B is the N-terminal “tail” domain of Hec1/NDC80, ...
ORGANISM(S): Homo sapiens (Human) 
2017-11-28 | PXD006892 | Pride
Human aurora a kinase hec1 
TranscriptomicsSelective Targeting of the Proliferating Compartment in Chronic Lymhocytic Leukemia by Inhibition or Downregulation of Aurora Kinases
Chronic lymphocytic leukemia (CLL) B-cells receive signals from the lymph node and bone marrow (BM) microenvironments that regulate their survival and proliferation. These signals and the pathways that propagate them to the interior of the cell represent potential targets for therapeutic interventio...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-30896 | biostudies-arrayexpress
UnknownCo-regulation of the antagonistic RepoMan:Aurora-B pair in proliferating cells.
Not available
S-EPMC7185888 | biostudies-literature
ModelsTang2019 - Pharmacology modelling of AURKB and ZAK interaction in TNBC
Aurora Kinase B and ZAK interaction model Equivalent of the stochastic model used in "Network pharmacology model predicts combined Aurora B and ZAK inhibition in MDA-MB-231 breast cancer cells" by Tang et. al. 2018. The only difference is cell division and partitioning of the components, which a...
2024-09-02 | BIOMD0000000940 | BioModels
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