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ProteomicsAurora B kinase disrupts the extended conformation of lattice-bound Kinesin-13 MCAK
We reveal that MCAK has a compact conformation in solution using cross-linking and electron microscopy. When MCAK is bound to the microtubule ends, it adopts an extended conformation with the N terminus and neck region of MCAK interacting with the microtubule. Also Aurora Bphosphorylation does not a...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD008215 | Pride
Mcak Phosphorylation Microtubules Aurora b 
ProteomicsSCFFbxw5 targets kinesin-13 proteins to facilitate ciliogenesis
Using substrate screening on protein microarrays we identified the kinesin-13 Kif2c/MCAK as a novel target of the ubiquitin E3 ligase SCF-Fbxw5. In cells, SCF-Fbxw5 ubiquitylates MCAK for proteasomal degradation during G2/M thereby facilitating ciliogenesis in the following G0 phase. Here, we perfor...
ORGANISM(S): Homo sapiens (Human) 
2021-08-12 | PXD026353 | Pride
Cullin-ring ligase / ubiquitin / fbxw5 / mcak / cilia 
UnknownMCAK associates with the tips of polymerizing microtubules.
Not available
S-EPMC2171944 | biostudies-literature
UnknownControl of MCAK degradation and removal from centromeres.
Not available
S-EPMC3390786 | biostudies-literature
UnknownMCAK/Kif2C centromeric activity level tunes K-fiber stability.
Not available
S-EPMC11870468 | biostudies-literature
UnknownMCAK recognizes the nucleotide-dependent feature at growing microtubule ends.
Not available
S-EPMC12629592 | biostudies-literature
UnknownMitotic centromere-associated kinesin (MCAK) mediates paclitaxel resistance.
Not available
S-EPMC3196137 | biostudies-literature
UnknownAurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interaction.
Not available
S-EPMC4034728 | biostudies-literature
UnknownAurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.
Not available
S-EPMC2441684 | biostudies-literature
UnknownMCAK Inhibitors Induce Aneuploidy in Triple-Negative Breast Cancer Models.
Not available
S-EPMC10340532 | biostudies-literature
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