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MetabolomicsLinking gastrointestinal microbiota and metabolome dynamics to clinical outcomes in pediatric hematopoietic stem cell transplantation

BACKGROUND: Hematopoietic stem cell transplantation is a curative procedure for a variety of conditions. Despite major advances, a plethora of adverse clinical outcomes can develop post-transplantation including graft-versus-host disease and infections, which remain the major cau...

2022-05-11 | MTBLS4065 | MetaboLights
MetabolomicsGut microbiome and metabolome dynamics as predictors of clinical outcomes in hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation (HSCT) induces significant alterations in the gut microbiome and metabolome, which influence transplant-related complications and surviv-al. This study longitudinally analyzed gut microbiota and metabolites at pre- (T1), peri- (T2), and post-transplant (T3) st...
2025-07-30 | MTBLS12365 | MetaboLights
TranscriptomicsExpression data from peripheral blood mononuclear cell in patients with type 1 diabetes before and after peripheral stem cell transplantation
Autologous nonmyeloablative hematopoietic stem cell transplantation (AHST) was the first therapeutic approaches that can improve beta cell function in type 1 diabetic (T1D) patients. This study was designed to investigate the potential mechanisms involved.We applied AHST to nine T1D patients diagnos...
ORGANISM(S): Homo sapiens 
2012-02-20 | E-GEOD-29908 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of lentivirally-transduced rhesus macaque CD34+ cells long-term following transplant
The occurrence of clonal perturbations and leukemia in patients transplanted with retrovirally-transduced autologous hematopoietic stem and progenitor cells (HSPCs) has stimulated extensive investigation, demonstrating that proviral insertions perturb adjacent proto-oncogene expression. Although enh...
ORGANISM(S): Macaca mulatta 
2013-11-05 | E-GEOD-46032 | biostudies-arrayexpress
UnknownSingle versus tandem autologous stem cell transplantation in newly diagnosed multiple myeloma.
Not available
S-EPMC11893441 | biostudies-literature
UnknownLate mortality and causes of death among long-term survivors after autologous hematopoietic stem cell transplantation.
Not available
S-EPMC10352032 | biostudies-literature
TranscriptomicsMouse cytokine antibody array
Tumors of hematopoietic stem cell transplantation (HSCT) or control mice were collected at day 14 post transplantation. Comprehensive analysis of cytokine levels were performed by using commercially available RayBio Mouse Cytokine Array G series III and IV (RayBiotech, Inc.) according to manufacture...
ORGANISM(S): Mus musculus 
2013-08-28 | E-MTAB-1761 | biostudies-arrayexpress
ProteomicsThe salivary proteome in relation to oral mucositis in autologous hematopoietic stem cell transplantation recipients: a labelled and label-free proteomics approach-TMTdata
Decreased salivary flow rates and/or changes in protein composition reported after autologous hematopoietic stem cell transplantation (ASCT) reduces the protective function of saliva. This might be associated with the development of oral mucositis (OM), an inflammation of the oral mucosa as a result...
ORGANISM(S): human oral bacteria ensemble Homo sapiens (Human) 
2023-07-10 | PXD033603 | Pride
Lc-ms Tmt-labelled proteomics Tmt-ms Label-free quantification Saliva Oral mucositis Autologous hematopoietic stem cell transplantation Multiple myeloma Dia-ms 
ProteomicsThe salivary proteome in relation to oral mucositis in autologous hematopoietic stem cell transplantation recipients: a labelled and label-free proteomics approach -DIAdata
Decreased salivary flow rates and/or changes in protein composition reported after autologous hematopoietic stem cell transplantation (ASCT) reduces the protective function of saliva. This might be associated with the development of oral mucositis (OM), an inflammation of the oral mucosa as a result...
ORGANISM(S): human oral bacteria ensemble Homo sapiens (Human) 
2023-07-10 | PXD033525 | Pride
Lc-ms Tmt-labelled proteomics Tmt-ms Label-free quantification Saliva Oral mucositis Autologous hematopoietic stem cell transplantation Multiple myeloma Dia-ms 
TranscriptomicsGene expression and epigenetic profiling of CD34+ hematopoietic progenitor cells in multiple sclerosis patients (expression)
Intense immunosuppression followed by autologous hematopoietic stem cell transplantation (aHSCT) is a potential treatment for patients suffering from aggressive multiple sclerosis (MS). However it remains unresolved whether autologous CD34+ hematopoietic progenitor cells of MS patients show gene exp...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-27688 | biostudies-arrayexpress
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