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MetabolomicsNanoinducers-mediated Mitochondria-Selective Degradation Enhance T Cell Immunotherapy Against Multiple Cancers

Cancer immunotherapy utilizing cytotoxic T lymphocytes (CTLs) has demonstrated significant promise in clinical applications, but cancer immunosuppressive mechanisms hamper further progress in T cell immunotherapy. Here we show a correlation between cancer cell mitochondria content and their resis...

2025-03-13 | MTBLS12284 | MetaboLights
ProteomicsBrain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
Supporting TMT MS data for paper (doi: 10.1016/j.neuron.2021.12.029) by Goldsmith J. et al., titled "Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons". Index of RAW files uploaded: AO3068-3079: Fractionated (12 fr...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-08-01 | MSV000092565 | MassIVE
GenomicsA lysosomal delivery mechanism required for autophagosome degradation
A lysosomal delivery mechanism required for autophagosome degradation
PRJEB62651 | ENA
ProteomicsThe V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation
Autophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules. Using a CRISPR/Cas9-based screen, we identify RNAseK, a highly conserved transmembrane protei...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-02 | PXD042079 | Pride
Dia-ms Autophagosome degradation Rnasek Lysosome 
ProteomicsA lysosomal delivery mechanism required for autophagosome degradation
Autophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules. We identified a highly conserved transmembrane protein named RNAseK as a novel regulator of a...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-05 | PXD042727 | Pride
Autophagy 
TranscriptomicsTranscriptional regulation by Pho23 modulates the frequency of autophagosome formation.
Autophagy as a conserved degradation and recycling machinery is important in normal development and physiology, and defects in this process are linked to many kinds of disease. Because too much or too little autophagy can be detrimental, the process must be tightly regulated both temporally and in m...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-24 | E-GEOD-57031 | biostudies-arrayexpress
TranscriptomicsAneuploidy-induced cellular stresses limit autophagic degradation.
An unbalanced karyotype, a condition known as aneuploidy, has a profound impact on cellular physiology and is a hallmark of cancer. Determining how aneuploidy affects cells is thus critical to understanding tumorigenesis. Here we show that aneuploidy interferes with the degradation of autophagosomes...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-60570 | biostudies-arrayexpress
Genomics
A lysosomal delivery mechanism required for autophagosome degradation
PRJNA977212 | ENA
UnknownMild MPP+ exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation.
Not available
S-EPMC5405408 | biostudies-literature
UnknownThe V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation.
Not available
S-EPMC11374810 | biostudies-literature
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