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MetabolomicsSphingolipid-dependent Dscam sorting regulates axon segregation
Neurons are highly polarized cells with distinct protein compositions in axonal and dendritic compartments. Cellular mechanisms controlling polarized protein sorting have been described for mature nervous system but little is known about the segregation in newly differentiated neurons. In a forward ...
2019-03-29 | MTBLS825 | MetaboLights
ProteomicsCentrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons
Local microtubule remodeling is critical for axon formation, the first step in establishing neuronal polarity. However, the function of the microtubule organizing centrosomes during the onset of axon formation, is still under debate. Here, we demonstrate that centrosomes play an essential role in co...
ORGANISM(S): Homo sapiens (Human) 
2021-02-12 | PXD020221 | Pride
Centrosome  axon  development  human  hipsc-derived neuron 
TranscriptomicsIMP2 axonal localization, RNA interactome, and function in development of axon trajectories
RNA-based regulatory mechanisms play important roles in the development and plasticity of neural circuits and neurologic disease. Developing axons provide a well suited model to study RNA-based regulation, and contain specific subsets of mRNAs that are locally translated and have roles in axon pathf...
ORGANISM(S): Mus musculus 
2016-08-02 | E-GEOD-83822 | biostudies-arrayexpress
GenomicsSEMA3B switches axon-axon to axon-glia interactions required for unmyelinated axon envelopment and integrity
SEMA3B switches axon-axon to axon-glia interactions required for unmyelinated axon envelopment and integrity
PRJNA1248491 | ENA
GenomicsProx1 inhibits axon outgrowth during central nervous system development
Prox1 inhibits axon outgrowth during central nervous system development
PRJNA666924 | ENA
TranscriptomicsTranscription profiling of Drosophila mutant and wild type embryos toinvestigate axon guidance
During the development of the Drosophila central nervous system the process of midline crossing is orchestrated by a number of guidance receptors and ligands. Many key axon guidance molecules have been identified in both invertebrates and vertebrates, but the transcriptional regulation of growth co...
ORGANISM(S): Drosophila melanogaster 
2008-06-15 | E-GEOD-6515 | biostudies-arrayexpress
GenomicsTet Controls Axon Guidance in Early Brain Development through Glutamatergic Signaling
Tet Controls Axon Guidance in Early Brain Development through Glutamatergic Signaling
PRJNA966247 | ENA
GenomicsA systematic exploration of the intrinsic mechanisms controling axon growth during development
A systematic exploration of the intrinsic mechanisms controling axon growth during development
PRJNA1329129 | ENA
GenomicsAxon-enriched lincRNA ALAE is required for axon elongation via regulating local mRNA translation
Axon-enriched lincRNA ALAE is required for axon elongation via regulating local mRNA translation
PRJNA636646 | ENA
TranscriptomicsEssential roles for the splicing regulator nSR100/SRRM4 during nervous system development
Alternative splicing (AS) generates vast transcriptomic complexity in the vertebrate nervous system. However, the extent to which trans-acting splicing regulators and their target AS regulatory networks contribute to nervous system development is not completely understood. To address these questions...
ORGANISM(S): Mus musculus 
2015-04-14 | E-GEOD-65818 | biostudies-arrayexpress
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