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Proteomics14-3-3θ Phosphorylation at S232 Reduces its Interactome and Regulates Axonal Trafficking
14-3-3 proteins impact protein-protein interactions (PPIs) that regulate neuronal functions. The 14-3-3θ isoform is protective in Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB) models. Human PD and DLB brains show increased 14-3-3θ phosphorylation at S232. To understand the impact of 1...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-25 | PXD071112 | Pride
Axonal trafficking Affinity-purification mass spectrometry 14-3-3θ Parkinson’s disease Dementia with lewy bodies 
ProteomicsComplex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
GABAB receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GB...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-13 | PXD012487 | Pride
Gabab receptors Cellular neuroscience Lc-ms/ms 
UnknownRegulation of axonal trafficking of cytochrome c oxidase IV mRNA.
Not available
S-EPMC2845174 | biostudies-literature
ProteomicsAutophagy lipidation machinery regulates microtubule dynamics to maintain axonal homeostasis
Axon integrity is crucial for neuronal function. To maintain axonal homeostasis neurons have evolved a unique organization of the microtubule (MT) cytoskeleton, which supports axonal morphology and provides tracks for intracellular transport. Although abnormal MT-based trafficking highlights the pat...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-25 | PXD011279 | Pride
Microtubule dynamics Neuron Autophagy Lc3 Axonal homoeostasis 
UnknownMolecular determinants of cytochrome C oxidase IV mRNA axonal trafficking.
Not available
S-EPMC5393917 | biostudies-literature
UnknownAnnexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons.
Not available
S-EPMC12706091 | biostudies-literature
UnknownLiver-X-receptor agonists rescue axonal degeneration in SPG11-deficient neurons via regulating cholesterol trafficking.
Not available
S-EPMC10655618 | biostudies-literature
UnknownThe SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons.
Not available
S-EPMC5035089 | biostudies-literature
UnknownIntra-axonal translation and retrograde trafficking of CREB promotes neuronal survival.
Not available
S-EPMC3153364 | biostudies-literature
UnknownOverexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy.
Not available
S-EPMC10754494 | biostudies-literature
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