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MetabolomicsMetabolomic Reprogramming Induced by Conjugative Acquisition of Carbapenemase-producing IncX3 Plasmid Revealed by Untargeted LC-MS/MS Profiling

This study aimed to elucidate the metabolic process of IncX3 plasmid within conjugated strains, by utilizing untargeted LC-MS/MS profiling. In this study, the blaNDM-5-carrying IncX3 plasmid was successfully conjugated into Escherichia coli J53, which was confirmed to enhance both carbap...

2026-09-27 | MTBLS13918 | MetaboLights
MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
MetabolomicsUntargeted LC-HRMS Based-Plasma Metabolomics Reveals 3-O-Methyldopa as a New Biomarker of Poor Prognosis in High-Risk Neuroblastoma
Neuroblastoma (NB) is the most common extracranial malignant tumor in children. Although the survival rate of NB has improved over the years, the outcome of NB still remains poor for over 30% of cases. A more accurate risk stratification remains a key point in the study of NB and the availability of...
2023-07-14 | MTBLS4294 | MetaboLights
MetabolomicsLC-HRMS based plasma metabolomics analysis for biomarker discovery of neuroblastoma: 3-O-methyldopa is a new biomarker of poor prognosis of metastatic disease
Not available
ORGANISM(S): Homo sapiens 
ST002238 | MetabolomicsWorkbench
TranscriptomicsActivation of autophagy by starvation and mTOR inhibition in three human cell lines
The aim of the project was to characterize changes in gene expression that are associated with induced autophagic flux. We engineered HeLa, HEK 293 and SH-SY5Y cell lines to express tandem-fluorecent LC3 (tf-LC3). The ratio of the red and green fluorophores indicated how much of the LC3 is in the ac...
ORGANISM(S): Homo sapiens 
2022-08-25 | E-MTAB-12020 | biostudies-arrayexpress
MetabolomicsMetabolomics profiling (GC-MS and LC-MS) for time-course differentiation of pre-B cells-like (B3 cell line) under the controlled induction of the transcription factor Ikaros (STATegra Project)
The main goal of the project is to develop a new generation of bioinformatics resources for the integrative analysis of multiple types of 'omics data. These resources include both novel statistical methodologies as well as user-friendly software implementations. STATegra methods address many aspects...
2016-12-15 | MTBLS283 | MetaboLights
ProteomicsFinding the LC3-interactors in senescent human A549 cells during influenza A virus infection
To screen age-related regulators of mitophagy, we examined LC3-interacting proteins by proximity-dependent biotin identification. LC3B was cloned into a mammalian expression vector tagged with a mitochondrial OMM-targeted APEX2 (mito-APEX) label for proximity-based identification of LC3-interacting ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD057110 | Pride
Influenza a virus Lc3 Ifection Senescent human cells 
ProteomicsReceptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy
Autophagosome formation requires multiple autophagy-related (ATG) factors. However, we find that a subset of autophagy substrates remains robustly targeted to the lysosome in the absence of several core ATGs, including the LC3 lipidation machinery. To address this unexpected result, we performed gen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000086106 | MassIVE
GenomicsExamination of hepatic SREBP-2 binding using ChIP-Seq
Sterol regulatory element binding proteins (SREBPs) are key transcriptional regulators of lipid metabolism. To define functional differences between the three mammalian SREBPs we are using genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-28082 | biostudies-arrayexpress
GenomicsAdiponectin pathway activation dampens inflammation and enhances alveolar macrophage fungal killing via LC3-associated phagocytosis
Adiponectin pathway activation dampens inflammation and enhances alveolar macrophage fungal killing via LC3-associated phagocytosis
PRJNA1118737 | ENA
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