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TranscriptomicsSAGE libraries from cell bodies and axons of NGF-differentiated sympathetic neurons
The subcellular localization of specific mRNAs is an evolutionary conserved mechanism that underlies the establishment of cellular polarity and specialized cell functions. In neurons, mRNA trafficking and local protein translation in dendrites provides an important mechanism that mediates synaptic ...
ORGANISM(S): Rattus norvegicus 
2010-01-30 | E-GEOD-13788 | biostudies-arrayexpress
ProteomicsUnbiased proteomic study of the axons of cultured rat cortical neurons
We have conducted quantitative proteomic analyses of the axons of cultured rat cortical neurons. Axons are isolated by using glass chips that enable the axons and their cell bodies of neurons to grow in separated regions on the chip surface. Proteins extracted from the isolated axons, as well as tho...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-04-17 | PXD005527 | Pride
Rat Axon Label-free quantification 2d-lc-msms Dimethyl-labeling quantitative proteomics 
TranscriptomicsChanges of axonal transcriptomes in response to local Abeta
We report that local application of Abeta(1-42) for 24h triggers changes in the localized transcriptome, while the transcriptome in cell bodies remains largely unchanged. Axonal and somatic mRNA profiles of rat embryonic hippocampal neurons grown in microfluidic chambers were generated by RNA-Seq in...
ORGANISM(S): Rattus norvegicus 
2015-07-14 | E-GEOD-70860 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse rat cortical axons from un-injured and injured animals isolated after 13 days in culture
Efficient growth cone regeneration requires protein synthesis in the adult mammalian brain and spinal cord. Recent evidence suggests that the local availability of protein synthesis machinery in adult mammalian axons may be an indicator of their regenerative capacity. Here we investigated the loca...
ORGANISM(S): Rattus norvegicus 
2009-01-14 | E-GEOD-11730 | biostudies-arrayexpress
GenomicsProfiling Kif5A RNA targets in sensory neuron axons
Profiling Kif5A RNA targets in sensory neuron axons
PRJNA595899 | ENA
GenomicsAnalysis of RNA localization in nucleolin deficient axons
Analysis of RNA localization in nucleolin deficient axons
PRJNA595902 | ENA
TranscriptomicsMicroarray analysis of R7 and R8 targeting
The formation of neuronal connections requires the precise guidance of developing axons towards their targets. In the Drosophila visual system, photoreceptor neurons (R cells) project from the eye into the brain. These cells are grouped into some 750 clusters comprised of eight photoreceptors or R-...
ORGANISM(S): Drosophila melanogaster 
2011-01-20 | E-GEOD-26717 | biostudies-arrayexpress
GenomicsRegulated local synthesis of ribosomal proteins maintains ribosome function in axons
Regulated local synthesis of ribosomal proteins maintains ribosome function in axons
PRJNA559103 | ENA
GenomicsRNAseq of fluidically isolated human and mouse motor neuron somas and axons in vitro
RNAseq of fluidically isolated human and mouse motor neuron somas and axons in vitro
PRJNA495499 | ENA
TranscriptomicsProfiling Kif5A RNA targets in sensory neuron axons
We previously identified that the RNA binding protein Nucleolin is localized to axons of DRG sensory neurons by interaction with the molecular motor Kinesin-1 (Kif5A) and subsequently localizes importin beta1 mRNA there (Perry et al., 2016). To further identify additional RNAs that are localized to ...
ORGANISM(S): Mus musculus 
2021-07-23 | GSE142099 | GEO
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