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ProteomicsB7-H4 post-translational modifications
B7-H4 functions as an immune checkpoint in the tumor microenvironment (TME). However, the post-translational modification (PTM) of B7-H4 and its translational potential in cancer remains incompletely understood. We found that ZDHHC3, a zinc finger DHHC-type palmitoyltransferase, palmitoylates B7-H4 ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD054393 | Pride
Lysosome Palmitoylation Breast cancers Abemaciclib B7-h4 
UnknownA B7-H4-Targeting Antibody-Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression.
Not available
S-EPMC11034955 | biostudies-literature
TranscriptomicsAnalysis of Wild Type and B7-H4-/- leukemia initial cells Transcriptomes
The goal of this study are to find the abonormally expressed genes of B7-H4-/- leukemia inital cells in MLL-AF9 induced AML mice by RNA-seq analysis.Methods: Lin- festival liver cells were isolated from WT and B7-H4-null mice and infected with MLL-AF9 retroviruses, then transplanted to the lethally ...
ORGANISM(S): Mus musculus 
2018-10-25 | GSE89161 | GEO
TranscriptomicsB7-H4 regulates β cell mass and insulin secretion by modulating cholesterol metabolism
Chronic islet inflammation is a hallmark of type 2 diabetes (T2D) and involves in the dysfunction of β cells. However, how β cells participate in this process remains unclear. Here, we report that the immune checkpoint molecule B7-H4(B7S1, B7x, VTCN1) expressed in β cells is critical to maintain β c...
ORGANISM(S): Mus musculus 
2024-12-19 | GSE268688 | GEO
UnknownPalmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion.
Not available
S-EPMC12062253 | biostudies-literature
UnknownAberrant expression of B7-H4 and B7-H5 contributes to the development of cutaneous squamous cell carcinoma.
Not available
S-EPMC11162363 | biostudies-literature
UnknownUpregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma.
Not available
S-EPMC5870586 | biostudies-literature
UnknownClinical significance and correlation of PD-L1, B7-H3, B7-H4, and TILs in pancreatic cancer.
Not available
S-EPMC9137118 | biostudies-literature
UnknownProgestogen-driven B7-H4 contributes to onco-fetal immune tolerance.
Not available
S-EPMC11344674 | biostudies-literature
UnknownB7-H4-deficient mice display augmented neutrophil-mediated innate immunity.
Not available
S-EPMC2647680 | biostudies-literature
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