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ProteomicsLFQ proteomics analysis of M. smegmatis treated with BacPROTACs.
To monitor selective degradation of ClpC1 and ClpC2 using BacPROTAC compounds in M. smegmatis we performed a LFQ proteomics analysis treating the cells at bactericidal compound concentration. We detected degradation of both proteins and additional dysregulation of the mycobacterial PQC system.
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2023-06-07 | PXD037235 | Pride
Antibiotics Tpd Bacprotac Protac Protein degradation 
UnknownHomo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria.
Not available
S-EPMC10914731 | biostudies-literature
UnknownBacPROTACs mediate targeted protein degradation in bacteria.
Not available
S-EPMC9240326 | biostudies-literature
ProteomicsAnalysis of the effect of ClpC1 directed antibiotics on ClpC1, ClpC2 and ClpC3 protein levels.
Ecumicin and Cyclomarin A (CymA) are known antimicrobial compounds that target the NTD of ClpC1. In proteomics analysis of compound treated M. smegmatis, two novel protein, ClpC2 and ClpC3, have been identified as strong interactors of those compounds in addition to ClpC1. In this study we used PRM ...
ORGANISM(S): Mycolicibacterium Smegmatis 
2023-06-07 | PXD037198 | panorama
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