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MetabolomicsComparative analysis of the adaptation of Staphylococcus aureus to internalization by different types of human non-professional phagocytic host cells (NMR assay)
Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival an...
2015-07-01 | MTBLS102 | MetaboLights
ProteomicsComparative analysis of the adaptation of Staphylococcus aureus to internalization by different types of human non-professional phagocytic host cells
We comparatively analyzed survival and physiological adaptation of S. aureus HG001 to two human lung epithelial cell lines (S9 and A549), and human embryonic kidney cells (HEK 293). Combining enrichment of bacteria from host-pathogen assays by cell sorting and quantitation of the pathogen´s proteome...
ORGANISM(S): Staphylococcus aureus 
2014-09-01 | PXD001003 | Pride
Cell culture infection model Bacterial adaptation to internalization in host cells Q exactive Staphylococcus aureus hg001 
ProteomicsProteomic characterization of the interplay of Staphylococcus aureus and human alveolar epithelial cells during infection - host cell proteins
Since infectious diseases caused by Staphylococcus aureus are still a major threat for human health we aimed to gain a detailed understanding of the molecular interplay of pathogen and host upon internalization by proteome analyses. In the present study we infected human alveolar epithelial A549 cel...
ORGANISM(S): Homo sapiens (Human) 
2015-08-05 | PXD002388 | Pride
Proteomics Host-pathogen interaction Epithelial cells Internalization Staphylococcus aureus 
ProteomicsProteomic characterization of the interplay of Staphylococcus aureus and human alveolar epithelial cells during infection - S. aureus proteins
Since infectious diseases caused by Staphylococcus aureus are still a major threat for human health we aimed to gain a detailed understanding of the molecular interplay of pathogen and host upon internalization by proteome analyses. In the present study we infected human alveolar epithelial A549 cel...
ORGANISM(S): Staphylococcus aureus 
2015-08-05 | PXD002384 | Pride
Proteomics Host-pathogen interaction Epithelial cells Internalization Staphylococcus aureus 
TranscriptomicsTranscription profiling of intramacrophage Burkholderia cenocepacia K56-2
Effect of internalization by macrophages on bacterial gene transcription in Burkholderia cenocepacia
ORGANISM(S): Burkholderia cenocepacia 
2011-12-07 | E-MEXP-3408 | biostudies-arrayexpress
ProteomicsAnalysis of secreted S. aureus proteins after isolation of phagosomes from infected human epithelial cells
Bacteria such as Staphylococcus aureus are generally engulfed by the host with a membrane when internalized by non-professional phagocytic host cells. These vacuoles then mature to phagosomes which can fuse with lysosomes enabling killing and digestion of the pathogen. Former proteome approaches enr...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2018-06-29 | PXD007885 | Pride
Host-pathogen-interaction Phagosomes Staphylococcus aureus Quantitative proteomics Single reaction monitoring (srm) Virulence factors 
UnknownComparative proteome analysis reveals conserved and specific adaptation patterns of Staphylococcus aureus after internalization by different types of human non-professional phagocytic host cells.
Not available
S-EPMC4117987 | biostudies-literature
UnknownA global view of Staphylococcus aureus whole genome expression upon internalization in human epithelial cells.
Not available
S-EPMC1924023 | biostudies-literature
UnknownActive bacterial modification of the host environment through RNA polymerase II inhibition.
Not available
S-EPMC7880420 | biostudies-literature
TranscriptomicsExpression data profile of A498 cells infected with E. coli 83972, mutants or stimualted with rNlpD
Unlike pathogens, which attack the host, commensal bacteria create a state of friendly coexistence. Here, we identify a new mechanism of bacterial adaptation to the host niche, where they reside. Asymptomatic carrier strains are shown to inhibit RNA Polymerase II (Pol II) in host cells by targeting ...
ORGANISM(S): Homo sapiens 
2020-12-11 | GSE162190 | GEO
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