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ProteomicsThe GTPase Rab39a matures phagosomes into MHC-I antigen-presenting compartments.
We have found Rab39a to be important in dendritic cells to promote antigen crosspresentation. As Rab39a is a Rab GTPase, we sought to determine how it influenced the contents of phagosomes. Thus we used SILAC using Rab39a CRISPR KO or reconstituted cells to determine phagosomal protein differences u...
ORGANISM(S): Mus musculus (Mouse) 
2019-12-11 | PXD016394 | Pride
Phagosomes Dendritic cell Rab39a 
GenomicsCandida albicans phagocytosed by macrophages: intact vs. ruptured phagosomes
Candida albicans phagocytosed by macrophages: intact vs. ruptured phagosomes
PRJNA613409 | ENA
ProteomicsAnalysis of secreted S. aureus proteins after isolation of phagosomes from infected human epithelial cells
Bacteria such as Staphylococcus aureus are generally engulfed by the host with a membrane when internalized by non-professional phagocytic host cells. These vacuoles then mature to phagosomes which can fuse with lysosomes enabling killing and digestion of the pathogen. Former proteome approaches enr...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2018-06-29 | PXD007885 | Pride
Host-pathogen-interaction Phagosomes Staphylococcus aureus Quantitative proteomics Single reaction monitoring (srm) Virulence factors 
ProteomicsTUBE pulldown of K63 ubiquitylated proteins from phagosomes
TUBE TAB2 pull down of K63 polyubiquitylated proteins from phagosomes isolated from mouse macrophages.
ORGANISM(S): Mus musculus (Mouse) 
2019-03-22 | PXD010478 | Pride
Ubiquitylation Macrophage Mouse Phagosome 
ProteomicsThe E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to infection
Phagocytosis is an essential process for the microbicidal function of professional phagocytes, in which phagosome maturation plays a critical role. Macrophage activation by interferons (IFN) increases their microbicidal activity, but delays phagosomal maturation. Here, we investigated the role of ub...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-20 | PXD026843 | Pride
Macrophage Phagosome Rnf115 Ubiquitin E3-ligase 
TranscriptomicsCandida albicans phagocytosed by macrophages: intact vs. ruptured phagosomes
Transcriptional profiling of Candida albicans after 3 h phagocytosis by vehicle DMSO-treated macrophages (intact, expanding phagosomes) or calcium chelator BAPTA-AM-treated macrophages (inhibits lysosomal repair of expanding phagosomes, leading to phagosome rupture) to determine the effect of preven...
ORGANISM(S): Candida albicans 
2020-10-05 | GSE147207 | GEO
ProteomicsTemporal and ligand effects on phagosome maturation
Systems biology analysis of temporally-resolved phagosome proteomes following uptake via key phagocytic receptors Macrophages operate at the forefront of innate immunity, and their discrimination of pathogenic versus “self” particles is critical for a number of responses including efficient pathogen...
ORGANISM(S): Mus musculus (Mouse) 
2015-09-10 | PXD000772 | Pride
Phagocytosis Macrophage Proteomics Mtraq Phagosome 
ProteomicsHuman p11-mediated re-direction of phagosomes to the recycling endosome-expulsion pathway induced by fungal pathogen
Aspergillus fumigatus invades pulmonary epithelial cells by induced phagocytosis, and survives for some time in phagosomes. Although dihydroxynaphthalene melanin on fungal conidia has been intensively investigated for its role in inhibiting phagosome maturation, a proportion of melanin-lacking mutan...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) Homo sapiens (Human) 
2023-03-13 | PXD030501 | Pride
Recycling endosome Exocytosis Pathogen Human p11 Rab7 Phagosome maturation Heat shock protein Anxa2 Rab11 
ProteomicsProteome analysis of WT and Borcs5 phagosomes from Raw264.7 macrophages
Hyperactive TLR7 signaling has long been appreciated as a driver of autoimmune disease in mouse models by breaking tolerance to self-nucleic acids1-5. Recently, the first monogenic mutations within TLR7 or its associated regulator Unc93b16,7 have been identified as causative agents of human lupus. T...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-22 | PXD040042 | Pride
Borcs5 Phagosomes 
UnknownMechanically induced actin-mediated rocketing of phagosomes.
Not available
S-EPMC1635377 | biostudies-literature
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