Rab39a - OmicsDI

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The GTPase Rab39a matures phagosomes into MHC-I antigen-presenting compartments.

We have found Rab39a to be important in dendritic cells to promote antigen crosspresentation. As Rab39a is a Rab GTPase, we sought to determine how it influenced the contents of phagosomes. Thus we used SILAC using Rab39a CRISPR KO or reconstituted cells to determine phagosomal protein differences u...

ORGANISM(S): Mus musculus (Mouse)

2019-12-11 | PXD016394 | Pride

Homo sapiens

RAB39A-knockdown spheres

PRJDB5563 | ENA

Prominent role of RAB39A-RXRB axis in cancer development and stemness.

Not available

S-EPMC5839406 | biostudies-literature

The GTPase Rab39a matures phagosomes into MHC-I antigen-presenting compartments.

This is the mass spec data from phagosomes of Rab39a deficient or Rab39a induced dendritic cell lines. For reference, see: Cruz FM, Colbert JD, Rock KL: The GTPase Rab39a matures phagosomes into MHC-I antigen-presenting compartments. . EMBO J (in press). Silac: Rab39a KO (Light), Rab39a induced (...

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

2019-11-21 | MSV000084611 | MassIVE

The GTPase Rab39a promotes phagosome maturation into MHC-I antigen-presenting compartments.

Not available

S-EPMC6960445 | biostudies-literature

Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion.

Not available

S-EPMC2787314 | biostudies-literature

Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages.

Not available

S-EPMC3862771 | biostudies-literature

C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy.