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TranscriptomicsGenome-wide transcriptome profiling of SK-Mel-28, UACC-62 and HCT-116 cells stably expressing scrambled shRNA and RAB7 shRNA
Purpose: Assess the transcriptional changes induced upon RAB7 knock-down in melanoma (SK-Mel-28 and UACC-62) and in colon cancer (HCT-116) cell lines. Methods: mRNA profiles of tumor cell lines (SK-Mel-28, UACC-62, HCT-116) stably expressing scrambled shRNA or RAB7 shRNA (harvested at day 3 after le...
ORGANISM(S): Homo sapiens 
2014-04-20 | E-GEOD-42735 | biostudies-arrayexpress
ProteomicsA trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol import. We characterise C18orf8 as a core subunit of the mammalian Mon1-Ccz1 guanid...
ORGANISM(S): Homo sapiens (Human) 
2020-10-29 | PXD021444 | Pride
Mon1 Lysosome Ccz1 Cholesterol C18orf8 Gef Npc1 Ldl Rab7 
GenomicsRab7 Deletion Drives Hepatocyte Apoptosis and Fibrogenesis in the Liver
Rab7 Deletion Drives Hepatocyte Apoptosis and Fibrogenesis in the Liver
PRJNA1179416 | ENA
GenomicsRAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension
RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension
PRJNA1019789 | ENA
ProteomicsThe Small GTPase Rab7 Regulates Release of Mitochondria in Extracellular Vesicles in Response to Lysosomal Dysfunction
Deletion of the small GTPase Rab7 in cells or adult mouse heart leads to increased secretion of EVs containing ubiquitinated cargos, including intact mitochondria. Mass spectrometry data of extracellular vesicles was obtained for proteomics.
ORGANISM(S): Mus musculus (Mouse) 
2023-08-22 | PXD037992 | Pride
Extracellular vesicles Mitochondria 
ProteomicsMacrophage SH3GLB1 is required for Rab7-1 mediated mitophagy in inflammation during acute lung injury
Acute lung injury (ALI) accompanied by an inflammatory response is an important complication after drowning. Macrophage activation and polarization are implicated in the inflammatory process of lipopolysaccharide (LPS)-induced ALI (LPS-ALI), but little is known about drowning-induced ALI (drowning-A...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-10 | PXD073650 | Pride
Acute lung injury  drowning  sh3glb1  rab7  mitophagy 
TranscriptomicsRab7 Deletion Drives Hepatocyte Apoptosis and Fibrogenesis in the Liver
BACKGROUND AND AIMS: Liver fibrosis (LF) is kept in check by regulatory machinery that switches off signaling pathways responsible for cell death and subsequent scar tissue formation. Hepatocyte injury is essential for the initiation and development of LF, yet the underlying mechanism remains elusiv...
ORGANISM(S): Mus musculus 
2026-10-01 | GSE280561 | GEO
TranscriptomicsRAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension
Pulmonary arterial hypertension (PAH) is a devastating and progressive disease with limited treatment options. Endothelial dysfunction plays a central role in development and progression of PAH, yet the underlying mechanisms are incompletely understood. The endosome-lysosome system is important to m...
ORGANISM(S): Homo sapiens 
2023-11-29 | GSE243774 | GEO
GenomicsGamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy
Gamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy
PRJNA830352 | ENA
ProteomicsUSP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7
The endosomal system is a highly dynamic multifunctional organelle, whose complexity is regulated in part by reversible ubiquitylation. Despite the wide-ranging influence of ubiquitin in endosomal processes, relatively few enzymes utilizing ubiquitin have been described to control endosome integrity...
ORGANISM(S): Homo sapiens (Human) 
2019-03-20 | PXD011899 | Pride
Endosomal trafficking Ubiquitin specific protease Ubiquitin Usp32 Rab gtpase 
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