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ProteomicsTaxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling
Taxanes are widely used chemotherapeutic agents that perturb cell division. They also exert effects during interphase, but the underlying mechanisms are poorly understood. Here, we show that taxanes activate RhoA signaling and induce actin remodeling by displacing the RhoA activator GEF-H1 from micr...
ORGANISM(S): Homo sapiens (Human) 
2026-08-20 | PXD079708 | Pride
Rhoa signaling Gef-h1 Microtubules 
TranscriptomicsIL-8 Confers Acquired Resistance to EGFR Inhibitors through Regulating Stem Cell-like Properties in Lung Cancer
Previous study has demonstrated that PC9/gef cells are resistant to gefitinib-induced aspoptosis. To investigate the regulators contributed to gefitinib resistance in lung cancer, we analyzed the gene expression profiles between PC9 and PC9/gef cells. Our results showed that IL-8 contributes to gefi...
ORGANISM(S): Homo sapiens 
2015-08-12 | E-GEOD-60189 | biostudies-arrayexpress
ProteomicsRheb and TRF1 PhastID mass spectrometric data
Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1 (mTORC1) to coordinate signaling cascades in response to nutrients and growth factors. Despite extensive studies, the guanine nucleotide exchange factor (GEF) that directly activates Rhe...
ORGANISM(S): Homo Sapiens 
2022-09-29 | PXD037078 |
ProteomicsA trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol import. We characterise C18orf8 as a core subunit of the mammalian Mon1-Ccz1 guanid...
ORGANISM(S): Homo sapiens (Human) 
2020-10-29 | PXD021444 | Pride
Mon1 Lysosome Ccz1 Cholesterol C18orf8 Gef Npc1 Ldl Rab7 
TranscriptomicsmiRNA array analysis following gefinitib/luteolin administration to PC-3 cells
To determine if any altered miRNA expression is actually involved in the growth inhibition and/or cell death induction by luteolin and/or gefitinib, we performed miR-array analysis using RNA from PC-3 cells after 24h of treatment with 60μM luteolin and/or 60μM gefitinib. PC-3 cells were treated fo...
ORGANISM(S): Homo sapiens 
2014-06-29 | E-GEOD-53178 | biostudies-arrayexpress
GenomicsHypoxia inhibits HUNK-mediated phosphorylation of GEF-H1 for epithelial-to-mesenchymal transition
Hypoxia inhibits HUNK-mediated phosphorylation of GEF-H1 for epithelial-to-mesenchymal transition
PRJNA840881 | ENA
GenomicsGEF-H1 mediated gene expression changes in BMDCs in response to microtubule destabilization
GEF-H1 mediated gene expression changes in BMDCs in response to microtubule destabilization
PRJNA558066 | ENA
ProteomicsSynaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD006326 | Pride
Mouse Neuron Gtp 
ProteomicsInteraction of the GEF SH3BP5 and its cognate GTPase Rab11
H/D exchange analysis of the GEF SH3BP5 and its interaction with the GTPase Rab11
ORGANISM(S): Homo sapiens (Human) 
2018-09-18 | PXD010586 | Pride
Hdx-ms Gef Hydrogen deuterium exchange Rab11 
GenomicsGEF-H1-IRF5 mediated gene expression changes in BMDM by MDP recognition
GEF-H1-IRF5 mediated gene expression changes in BMDM by MDP recognition
PRJNA523187 | ENA
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