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ProteomicsA trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol import. We characterise C18orf8 as a core subunit of the mammalian Mon1-Ccz1 guanid...
ORGANISM(S): Homo sapiens (Human) 
2020-10-29 | PXD021444 | Pride
Mon1 Lysosome Ccz1 Cholesterol C18orf8 Gef Npc1 Ldl Rab7 
UnknownSystematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux.
Not available
S-EPMC5730722 | biostudies-literature
UnknownA trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.
Not available
S-EPMC7642327 | biostudies-literature
UnknownMechanistic insights into the GEF activity of the human MON1A/CCZ1/C18orf8 complex.
Not available
S-EPMC12342132 | biostudies-literature
UnknownNovel Indel Variation of NPC1 Gene Associates With Risk of Sudden Cardiac Death.
Not available
S-EPMC9035640 | biostudies-literature
UnknownCRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity.
Not available
S-EPMC6911768 | biostudies-literature
TranscriptomicsTranscription profiling of Toxoplasma gondii developmental time series
Asexual development in Toxoplasma gondii is a vital aspect of the parasite's life cycle, allowing transmission and avoidance of the host immune response. Differentiation of rapidly dividing tachyzoites into slowly growing, encysted bradyzoites involves significant changes in both physiology and morp...
ORGANISM(S): Toxoplasma gondii 
2005-07-21 | E-SMDB-1428 | biostudies-arrayexpress
TranscriptomicsTachyzoite to bradyzoite differentiation.
Asexual development in Toxoplasma gondii is a vital aspect of the parasite's life cycle, allowing transmission and avoidance of the host immune response. Differentiation of rapidly dividing tachyzoites into slowly growing, encysted bradyzoites involves significant changes in both physiology and morp...
ORGANISM(S): Toxoplasma gondii 
2005-08-13 | E-GEOD-3120 | biostudies-arrayexpress
TranscriptomicsProspective isolation of a bipotential clonogenic liver progenitor cell in adult mice
The molecular identification of adult hepatic stem/progenitor cells has been hampered by the lack of truly specific markers. To isolate putative adult liver progenitor cells, we used cell surface-marking antibodies, including MIC1-1C3, to isolate subpopulations of liver cells from normal adult mice ...
ORGANISM(S): Mus musculus 
2011-05-07 | E-GEOD-29121 | biostudies-arrayexpress
TranscriptomicsCell surface markers that distinguish human beta cells and alpha cells
The goal of this experiment is to determine cell surface markers that are present in human beta cells or alpha cells but not both. Cells from human islets were FACS sorted and prepared as matched pairs of beta and alpha cells preparations.
ORGANISM(S): Homo sapiens 
2011-06-10 | E-MTAB-459 | biostudies-arrayexpress
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