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ProteomicsNHS-Ester Tandem Labeling in One Pot for 48-Plex Proteomics
Stable-isotope labeling strategies are extensively used for multiplex quantitative proteomics. Hybrid isotope labeling strate-gies that combine the use of isotopic mass difference labeling and isobaric tags can greatly increase sample multiplexity. In this work, we present a novel hybrid isotope lab...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD024780 | Pride
48-plex proteomics Tmtpro Mtraq 
ProteomicsQuantitative proteome for C.elegans by 3plex mTRAQ
Vesicle-mediated transport is a fundamental part of the secretory and endocytic pathways. In addition to their role in membrane protein trafficking, Arf-like protein subfamily of small GTPases also plays an important role in development, maintenance of Golgi structure and function. Proper protein tr...
ORGANISM(S): Caenorhabditis elegans 
2022-02-17 | PXD026411 | Pride
C. elegans Mtraq Lc-ms/ms 
ProteomicsiTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics
Mertins P, Udeshi ND, Clauser KR, Mani DR, Patel J, Ong, SE, Jaffe JD, Carr SA. Mol Cell Proteomics 2012, mcp.M111.014423. doi:10.1074/mcp.M111.014423. Tranche_hash:5cHw5Rj36vYNshNpy8k4nojtPyW27N/FHcImna3+zw4QV6KIlLOg3i6zesWBdWkEX608MEgdxWuVyKvvdOgB9BAanesAAAAAAACEzw==
2013-11-20 | MSV000078495 | MassIVE
ProteomicsTemporal and ligand effects on phagosome maturation
Systems biology analysis of temporally-resolved phagosome proteomes following uptake via key phagocytic receptors Macrophages operate at the forefront of innate immunity, and their discrimination of pathogenic versus “self” particles is critical for a number of responses including efficient pathogen...
ORGANISM(S): Mus musculus (Mouse) 
2015-09-10 | PXD000772 | Pride
Phagocytosis Macrophage Proteomics Mtraq Phagosome 
ProteomicsAn Optogenetic-Phosphoproteomic Approach Links Akt Activation to Dynamic Temporal Changes in Signaling in Endothelial Cells
The serine/threonine kinase Akt is a central node in cell signaling. While aberrant Akt activation underlies the development of a variety of human diseases, how different patterns of Akt-dependent phosphorylation dictates downstream signaling and phenotypic outcomes remains largely enigmatic. Herein...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD034957 | Pride
Phosphoproteomics Dia-ms Akt Akt1 Mtraq Optogenetics Time course 
ProteomicsQuantitative phosphoproteomics analysis of ERBB3/ERBB4 signaling
The four members of the epidermal growth factor receptor (EGFR/ERBB) family form homo- and heterodimers which mediate ligand-specific regulation of many key cellular processes in normal and cancer tissues. While signaling through the EGFR has been extensively studied on the molecular level, signal t...
ORGANISM(S): Mus musculus (Mouse) 
2016-01-15 | PXD002665 | Pride
Erbb3 Erbb4 Phosphoproteomics 
ProteomicsPhagosome proteome of activated murine macrophage
Proteomics of carboxylated polystyrene bead (1.0 um) phagosomes from murine bone marrow-derived macrophages. cells were either resting or treated with 100 U/ml IFN-γ (PeproTech) and 100 ng/ml LPS (Sigma) for 24 h, 20 ng/ml Interleukin-4 (IL4) (BD Pharmingen) for 48 h, 20 ng/ml Interleukin-13 (IL13),...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-22 | PXD004520 | Pride
Lps Il13 Endosome Il10 Phagosome Mouse Macrophage Cytokine Reprogrammed Lysosome Interleukin-4 Interleukin-10 Interleukin-13 Interferon-gamma Il4 
ProteomicsPhosphodiesterase 10A inhibition improves cortico-basal ganglia function in Huntington’s disease models
Using Huntington’s disease (HD) mouse models that quantitatively replicate the reduction of striatal Phoshodiesterase 10 (PDE10) levels in manifest Huntington’s disease patients, we demonstrate the potential therapeutic benefit of PDE10 inhibition on correcting basal ganglia circuitry deficits thoug...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-02 | PXD005138 | Pride
Huntington's disease  proteomics  phosphoproteomics pde10a striatum 
UnknownInfluence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry.
Not available
S-EPMC3033980 | biostudies-literature
ProteomicsmTRAQ labeled natural proteome from HeLa
To identify proteotypic peptides, HeLa cells digest labeled with mTRAQdelta0 were extensively fractionated and analyzed by LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2016-12-07 | PXD001396 | Pride
Hela proteome Lc-ms/ms 
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