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MetabolomicsFFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights
GenomicsAlcanivorax sp. IL4
Alcanivorax sp. IL4 Genome sequencing
PRJNA161065 | ENA
TranscriptomicsEmodin inhibits macrophage alernative activation [Control-IL4-Emodin]
In order to fully characterize emodin's effects on macrophage alternative activation, peritoneal macrophages were stimulated with IL4 with or without emodin and gene expression was analyzed using a whole genome microarray. Emodin significantly attenuated the IL4 induced changes in a large percentage...
ORGANISM(S): Mus musculus 
2016-07-04 | E-GEOD-73309 | biostudies-arrayexpress
TranscriptomicsWT and FcgKO peritoneal MF response to IL4
Emerging data suggest that many immunoreceptors, all of which use a conserved ITAM-module for their signaling, can couple with members of additional classes of membrane receptors to deliver unique signal(s) to the cell. Using functional and gene expression analysis we describe the role for the tonic...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-54823 | biostudies-arrayexpress
ProteomicsPhagosome proteome of activated murine macrophage
Proteomics of carboxylated polystyrene bead (1.0 um) phagosomes from murine bone marrow-derived macrophages. cells were either resting or treated with 100 U/ml IFN-γ (PeproTech) and 100 ng/ml LPS (Sigma) for 24 h, 20 ng/ml Interleukin-4 (IL4) (BD Pharmingen) for 48 h, 20 ng/ml Interleukin-13 (IL13),...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-22 | PXD004520 | Pride
Lps Il13 Endosome Il10 Phagosome Mouse Macrophage Cytokine Reprogrammed Lysosome Interleukin-4 Interleukin-10 Interleukin-13 Interferon-gamma Il4 
GenomicsA549 cell Next Gen sequencing (RNA-seq) for differential gene expression of untreated versus IL4 or IL4+ALOX15 siRNA treated cells
A549 cell Next Gen sequencing (RNA-seq) for differential gene expression of untreated versus IL4 or IL4+ALOX15 siRNA treated cells
PRJNA720719 | ENA
GenomicsIL4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation
IL4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation
PRJNA648353 | ENA
UnknownPrediction of IL4 inducing peptides.
Not available
S-EPMC3893860 | biostudies-literature
GenomicsTranscriptional effects of IL4 on adipocyte progenitors (APs) [RNA-seq]
Transcriptional effects of IL4 on adipocyte progenitors (APs) [RNA-seq]
PRJNA1336175 | ENA
GenomicsPolysome-profiling of IL4 or INFG polarized BMDMs
Polysome-profiling of IL4 or INFG polarized BMDMs
PRJNA641348 | ENA
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