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TranscriptomicsTargeted ErbB3 loss in mammary organoids harvested from ErbB3 DOX-KO mice +/- DOX treatment
Mammary organoids harvested from ErbB3 DOX-KO mice, which utilize MMTV-Cre transgene expression in the LE to cause genomic recombination at floxed ErbB3 alleles in ErbB3FL/FL were cultured in the presence or absence of doxycycline to induce ErbB3 loss. The gene expression shift following DOX-induce...
ORGANISM(S): Mus musculus 
2012-01-04 | E-GEOD-32129 | biostudies-arrayexpress
TranscriptomicsNRG1/ERBB3 signaling in melanocyte Melan-Ink4a cells
Neuregulin (NRG) signaling through the receptor tyrosine kinase, ERBB3, is required for embryonic development, and dysregulated signaling has been associated with cancer progression. Here, we show that NRG1/ERBB3 signaling inhibits melanocyte (MC) maturation and promotes undifferentiated, migratory ...
ORGANISM(S): Mus musculus 
2010-05-07 | E-GEOD-21463 | biostudies-arrayexpress
TranscriptomicsConditional loss of ErbB3 delays mammary gland hyperplasias induced by mutant PIK3CA but does not affect mammary tumor latency, gene expression or signaling
Mutations in PIK3CA, the gene encoding the p110α subunit of PI3K, induce transformation of mammary epithelial cells (MEC). Studies suggest the transforming action of mutant PIK3CA requires binding to activated receptor tyrosine kinases or adaptors. We examined in transgenic mice if ErbB3, a powerful...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-43037 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteomics analysis of ERBB3/ERBB4 signaling
The four members of the epidermal growth factor receptor (EGFR/ERBB) family form homo- and heterodimers which mediate ligand-specific regulation of many key cellular processes in normal and cancer tissues. While signaling through the EGFR has been extensively studied on the molecular level, signal t...
ORGANISM(S): Mus musculus (Mouse) 
2016-01-15 | PXD002665 | Pride
Erbb3 Erbb4 Phosphoproteomics 
TranscriptomicsAlterations in Cell Growth and Signaling in ErbB3 Binding Protein -1 (Ebp1) Deficient Mice
Background: The ErbB3 binding protein-1 (Ebp1) belongs to a family of DNA/RNA binding proteins implicated in cell growth, apoptosis and differentiation. However, the physiological role of Ebp1 in the whole organism is not known. Therefore, we generated Ebp1-deficient mice carrying a gene trap insert...
ORGANISM(S): Mus musculus 
2009-03-31 | E-GEOD-13718 | biostudies-arrayexpress
GenomicsStromal Erbb3 shapes uterine gland morphogenesis
Stromal Erbb3 shapes uterine gland morphogenesis
PRJNA1334398 | ENA
TranscriptomicsTranscription profiling of human prostate cancer cell line to determine Ebp1 effect in prostate cancer
Therapies targeting the androgen receptor are critical for treatment of hormone refractory prostate cancer. We have previously demonstrated that Ebp1, a protein isolated by its ability to bind ErbB3, is a downstream effector of heregulin activated pathways and an AR corepressor. As Ebp1 is decreased...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-12200 | biostudies-arrayexpress
TranscriptomicsA secreted isoform of ErbB3 promotes osteomectin expression in bone
The propensity for prostate cancer to metastasize to bone led us and others to propose that bidirectional interaction between prostate cancer cells and bone are critical for the preferential metastasis of PCa to bone. We previous identified a secreted isoform of ErbB3 (p45-sErbB3) from the bone mar...
ORGANISM(S): Mus musculus 
2008-05-01 | E-GEOD-8001 | biostudies-arrayexpress
ModelsTelesco2011_HER3-ErbB3-RTK_SignalingNetwork
This model is from the article: A multiscale modeling approach to investigate molecular mechanisms of pseudokinase activation and drug resistance in the HER3/ErbB3 receptor tyrosine kinase signaling network. Telesco SE, Shih AJ, Jia F, Radhakrishnan R. Mol Biosy...
2005-01-01 | MODEL1102210001 | BioModels
TranscriptomicsTargeted ErbB3 loss in mammary organoids harvested from ErbB3 DOX-KO mice +/- DOX treatment
Mammary organoids harvested from ErbB3 DOX-KO mice, which utilize MMTV-Cre transgene expression in the LE to cause genomic recombination at floxed ErbB3 alleles in ErbB3FL/FL were cultured in the presence or absence of doxycycline to induce ErbB3 loss. The gene expression shift following DOX-induced...
ORGANISM(S): Mus musculus 
2012-01-04 | GSE32129 | GEO
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