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In order to understand what genes were regulated by the presence of a new fusion transcript (LMO3-BORCS5), we stably transfected either an empty vector (pc3.1) or vector containing LMO3-BORCS5 sequence into A673 human Ewing sarcoma cell line. 2 different clones were obtained for each condition (4 co...
ORGANISM(S): Homo sapiens 
To understand the function of BORCS5 in mRNA tranport, RNA-seq analysis was performed on axons and neurons from WT and BORCS5-KO human i3Neurons.
ORGANISM(S): Homo sapiens 
2024-02-09 | GSE225479 | GEO
Hyperactive TLR7 signaling has long been appreciated as a driver of autoimmune disease in mouse models by breaking tolerance to self-nucleic acids1-5. Recently, the first monogenic mutations within TLR7 or its associated regulator Unc93b16,7 have been identified as causative agents of human lupus. T...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-22 | PXD040042 | Pride
Lysosome-coupled mRNA transport maintains mitochondrial and ribosomal homeostasis in the axon
Microarray analysis of A673 cell line stably transfected with empty vector pc3.1 versus A673 cell lines stably transfected with pcDNA3.1-LMO3-BORCS5
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