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MetabolomicsSalivary MUC5B Modulation of Glucose Metabolism in Early Oral Biofilms
To investigate how early mono- and dual species biofilms of oral Actinomyces naeslundii and Streptococcus gordonii clinical isolates metabolized glucose in the presence of the complex salivary mucin MUC5B, this study employed NMR-based metabolomics with interpretation of network integration. Untarge...
2024-09-11 | MTBLS10078 | MetaboLights
MetabolomicsEvidence for proline utilisation by oral bacterial biofilms grown in saliva
Not available
ORGANISM(S): Multi-species non-defined biofilm consortium 
ST001433 | MetabolomicsWorkbench
MetabolomicsA novel targeted/untargeted GC-Orbitrap metabolomics methodology applied to Candida albicans and Staphylococcus aureus biofilms

INTRODUCTION: Combined infections from Candida albicans and Staphylococcus aureus are a leading cause of death in the developed world. Evidence suggests that Candida enhances the virulence of Staphylococcus - hyphae penetrate through tissue bar...

2017-02-20 | MTBLS370 | MetaboLights
TranscriptomicsTranscription profiling of P. aeruginosa biofilms treated with tobramycin grown on CFBE41o- cells
We grew Pseudomonas aeruginosa biofilms on CFBE41o- human airway cells in culture, and we treated these biofilms with tobramycin. Microarray analysis was performed to gain an understanding of the global transcriptional changes that occur during antibiotic treatment. Experiment Overall Design: We co...
ORGANISM(S): Pseudomonas aeruginosa 
2008-06-18 | E-GEOD-9989 | biostudies-arrayexpress
TranscriptomicsGlutaraldehyde resistance mechanisms in Pseudomonas fluorescens and Pseudomonas aeruginosa biofilms
The objective of the current study was to understand the glutaraldehyde resistance mechanisms in P. fluorescens and P. aeruginosa biofilms. Glutaraldehyde is a common biocide used in various industries to control the microbial growth. Recent reports of emergence of glutaraldehyde resistance in sever...
ORGANISM(S): Pseudomonas fluorescens 
2015-04-06 | E-GEOD-64448 | biostudies-arrayexpress
ProteomicsMigration of Acanthamoeba through Legionella biofilms is regulated by bacterial quorum sensing, effectors and the flagellum
Legionella pneumophila is a Gram-negative, environmental bacterium, which causes the life-threatening pneumonia Legionnaires’ disease. The facultative intracellular bacterium forms biofilms and employs the Icm/Dot type IV secretion system (T4SS) to replicate in amoebae and macrophages. The Legionell...
ORGANISM(S): Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) 
2022-06-08 | PXD030337 | Pride
Response regulator Sensor kinase Cell-cell communication Flagellum Legionella Cell migration Acanthamoeba Transcription factor Biofilm Quorum sensing Amoeba Bacterial adherence 
ProteomicsMechanistic insight into elasnin’s inhibitory effect on marine biofilms
One-week marine biofilms grown on elasnin-based coatings subjected to proteomics analysis.
ORGANISM(S): Pseudoteredinibacter isoporae 
2023-06-21 | PXD034385 | Pride
Marine Proteomics Marine biofilms Elasnin Biofilms 
TranscriptomicsStaphylococcus epidermidis biofilms transcriptome alterations upon incubation with whole human blood
The ability of S. epidermidis to withstand the high bactericidal activity of the hostM-bM-^@M-^Ys blood is crucial for its systemic dissemination. Hence, in order to identify genes and pathways involved in the bacteriumM-bM-^@M-^Ys survival in human blood, we have characterized the transcriptome of ...
ORGANISM(S): Staphylococcus epidermidis 
2014-08-29 | E-GEOD-52111 | biostudies-arrayexpress
ProteomicsRemodeling of the neutrophil proteome upon exposure to Pseudomonas aeruginosa biofilms
Neutrophils are the most prominent cell in the immune system, accounting for 70% of circulating leukocytes, and acting as the first line of defense against various invading pathogens. For example, neutrophils engage in phagocytosis, degranulation, and neutrophil extracellular trap formation to respo...
ORGANISM(S): Homo sapiens (Human) Pseudomonas aeruginosa PAO1 
2024-10-14 | PXD056790 | Pride
Neutrophils Total proteome Pseudomonas aeruginosa Biofilms 
ProteomicsVitamin C inhibits bacterial biofilms by affecting the synthesis of the extracellular polymeric matrix
Extracellular polymeric substances (EPS) produced by bacteria form a matrix for the complex three-dimensional architecture of biofilms. The EPS matrix of a biofilm is primarily composed of polysaccharides, proteins and extracellular DNA (eDNA). In addition to supporting the community structure, the ...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2017-12-19 | PXD007533 | Pride
Bacteria Mass spectrometry Label-free quantification 
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