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TranscriptomicsPancreatic cancer organoid
Organoids from KPC pancreatic tumor tissue was treated with growth medium or conditional medium of mast cells treated with WT or BAG6 KO EVS of Pan02.
ORGANISM(S): Mus musculus 
2024-12-31 | E-MTAB-13570 | biostudies-arrayexpress
ProteomicsExtracellular vesicles from pancreatic cancer cells activate mast cells which in turn promote tumor cell proliferation and establish a tumor-supportive microenvironment
Background and aim: Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer progression. Driver genes directing EV function, the EV-recipient cells, as well as their cellular response to EV uptake remain, however, to be identified. To address th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-06 | MSV000093583 | MassIVE
ProteomicsExosome-dependent immune surveillance at the metastatic niche requires BAG6
Extracellular vesicles (EVs) secreted by tumor cells are able to establish a pre-metastatic niche in distant organs, or on the contrary, exert anti-tumor activity. The mechanisms directing distinct EV functions are unknown. Using the B-16V transplantation mouse melanoma model we demonstrate that EVs...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010677 | Pride
Exosomes Evs Bag6 
TranscriptomicsExosomes dependent immune surveillance at the metastatic niche requires BAG6
Mice were intravenously injected with extracellular vesicles (EVs) isolated from B16V wt (n=3) or BAG6KO (n=3) cells or with PBS (n=3) as a control for 4 weeks on a weekly basis. Since B-16V melanoma cells colonise the lung upon intravenous injection and referring to current literature, we hypothesi...
ORGANISM(S): Mus musculus 
2019-11-29 | E-MTAB-7119 | biostudies-arrayexpress
ProteomicsMitochondrial antiviral-signalling protein is a client of the BAG6 QC complex
The heterotrimeric BAG6 complex coordinates the direct handover of newly synthesised tail-anchored (TA) membrane proteins from an SGTA-bound preloading complex to the endoplasmic reticulum (ER) delivery component TRC40. In contrast, defective precursors, including aberrant TA proteins, form a stable...
ORGANISM(S): Homo sapiens (Human) 
2022-04-26 | PXD030129 | Pride
Bioid Mavs Bioid2 Bag6 
TranscriptomicsscRNAseq of tumor and blood of mice infected with Pan02 cells, WT and BAG6 deletion
Mice were infected with the pancreatic cancer cell line Pan02 (into their pancreas). 30 days later, pancreas was extracted, cells digested and BD Rhapsody RNAseq targeted against the MM immune panel was performed.
ORGANISM(S): Mus musculus 
2024-12-30 | E-MTAB-13573 | biostudies-arrayexpress
ProteomicsSILAC-based quantitative proteomics using mass spectrometry identifies BAG-6 mediated changes in the subproteome degraded by endosomal microautophagy (eMI).
To identify the subproteome degraded by endosomal microautophagy (eMI) in a Bag6-dependent manner, we compared the proteome of late endosomal compartments LE/MVBs isolated from control(wild type) and Bag6(-) cells using SILAC labeling and quantitative proteomics.
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD046760 | Pride
Mouse jaws Bag-6 ko Late endosomes 
GenomicsExosomes dependent immune surveillance at the metastatic niche requires BAG6
Exosomes dependent immune surveillance at the metastatic niche requires BAG6
PRJEB28128 | ENA
UnknownCytoplasmic control of Rab family small GTPases through BAG6.
Not available
S-EPMC6446207 | biostudies-literature
UnknownThe association of BAG6 with SGTA and tail-anchored proteins.
Not available
S-EPMC3606182 | biostudies-literature
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