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TranscriptomicsTranscription profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects
Down syndrome (DS) is the result of trisomy chromosome 21 but the mechanisms by which the genotype leads to the characteristic disease phenotype are unclear. We performed a microarray study using human adult brain tissue (dorsolateral prefrontal cortex) from DS subjects and healthy controls to chara...
ORGANISM(S): Homo sapiens 
2009-04-23 | E-GEOD-5390 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human brain tissue from subjects with bipolar disorder and healthy controls
Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefro...
ORGANISM(S): Homo sapiens 
2007-06-24 | E-GEOD-5388 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls
This SuperSeries is composed of the following subset Series:; GSE5388: Adult postmortem brain tissue (dorsolateral prefrontal cortex) in subjects with bipolar disorder; GSE5389: Adult postmortem brain tissue (ortibtofrontal cortex) in subjects with bipolar disorder; Bipolar affective disorder is a s...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5392 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human post-mortem brain tissue (orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls
Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (orbitofrontal corte...
ORGANISM(S): Homo sapiens 
2007-07-03 | E-GEOD-5389 | biostudies-arrayexpress
TranscriptomicsGene expression data from primate postnatal brain development - superior frontal gyrus
In development, timing is of the utmost importance, and the timing of various developmental processes are often changed during evolution. During human evolution sexual maturation has been delayed relative to other primates and this may have played a critical role for both the increase of human brain...
ORGANISM(S): Homo sapiens 
2009-03-09 | E-GEOD-15163 | biostudies-arrayexpress
TranscriptomicsComparison of expression profiles of once and three time linearly amplified samples
In order to assess the impact of three rounds of linear amplification on the technical reproducibility of gene expression measurements, we performed twelve microarray experiments. We analysed mouse RNA from cortex, cerebellum and liver from one individual. One RNA sample of 5µg from each of the thr...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21389 | biostudies-arrayexpress
TranscriptomicsGene expression changes during primate postnatal brain development
In development, timing is of the utmost importance, and the timing of various developmental processes are often changed during evolution. During human evolution sexual maturation has been delayed relative to other primates and this may have played a critical role for both the increase of human brain...
ORGANISM(S): Macaca mulatta 
2009-03-09 | E-GEOD-11512 | biostudies-arrayexpress
TranscriptomicsLaser capture microdissection of endothelial and neuronal cells from human dorsolateral prefrontal cortex
We used laser capture microdissection to isolate both microvascular endothelial cells and neurons from post mortem brain tissue from patients with schizophrenia and bipolar disorder and healthy controls. RNA was isolated from these cell populations, amplified, and analysed using Affymetrix HG133plus...
ORGANISM(S): Homo sapiens 
2008-12-18 | E-GEOD-12679 | biostudies-arrayexpress
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