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ProteomicsProteomic study of baicalein effects on LPS-primed BV2 microglia
To comprehensively study the intracellular signaling changes and explore the underlying mechanisms of baicalein-mediated microglial responses, we employed systemic proteomic approach, using target-free SWATH mass spectra (SWATH-MS), focusing on intracellular proteins. BV2 cells were treated with LPS...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-14 | PXD030447 | Pride
Baicalein Microglia 
ProteomicsLC-MS/MS of baicalein-regulated human lung fibroblast
Here, we showed that baicalein suppressed transforming growth factor β1 (TGF β1)-stimulated the production of type I collagen in lung fibroblast MRC-5 cells. By applying SILAC-based proteomic technology, 158 proteins were identified as baicalein-modulated proteins in TGF β1-stimulated the accumulati...
ORGANISM(S): Homo sapiens (Human) 
2020-09-21 | PXD016167 | Pride
Human  lung fibroblast  baicalein  lc-ms/ms 
GenomicsExpression data from baicalein treated C. elegans
Expression data from baicalein treated C. elegans
PRJNA556638 | ENA
TranscriptomicsExpression data from baicalein treated C. elegans
Effects of baicalein in C. elegans gene expression is studied, as our results indicate a lifespan extension effect produced by this molecule. Microarrays were used to detail the global programme of gene expression underlying the lifespan extension and identified distinct classes of up/down-regulated...
ORGANISM(S): Caenorhabditis elegans 
2021-03-11 | GSE134775 | GEO
GenomicsLncRNA expression profiling of hepatocellular carcinoma cell line BEL-7402 treated with baicalein
Baicalein, a purified flavonoid compound with defined chemical structure extracted from the dry roots of Scutellaria radix that is a broadly used herb in China, has been proved to possess significant anti-hepatoma activity by inhibiting cell proliferation, invasion, metastasis and inducing apoptosis...
ORGANISM(S): Homo sapiens 
2018-03-01 | GSE95504 | GEO
GenomicsMicroRNA expression profiling of hepatocellular carcinoma cell line BEL-7402 treated with baicalein
Baicalein, a purified flavonoid compound with defined chemical structure extracted from the dry roots of Scutellaria radix that is a broadly used herb in China, has been proved to possess significant anti-hepatoma activity by inhibiting cell proliferation, invasion, metastasis and inducing apoptosis...
ORGANISM(S): Homo sapiens synthetic construct 
2017-08-15 | GSE85511 | GEO
TranscriptomicsBaicalein Alleviates Acute-on-Chronic Liver Failure by Promoting TREM2-dependent Macrophage Polarization
Liver tissues from C57BL/6 mice with an ACLF model, subjected to either baicalein treatment or saline treatment, were collected. Bulk-RNA sequencing of liver tissues was used to explore the potential molecular mechanism of baicalein in alleviating ACLF.
ORGANISM(S): Mus musculus 
2025-12-31 | GSE248293 | GEO
GenomicsBaicalein Alleviates Acute-on-Chronic Liver Failure by Promoting TREM2-dependent Macrophage Polarization
Baicalein Alleviates Acute-on-Chronic Liver Failure by Promoting TREM2-dependent Macrophage Polarization
PRJNA1043172 | ENA
Genomics
Baicalein inhibits Candida auris
PRJNA1431181 | ENA
UnknownThe interaction between cucurbit[8]uril and baicalein and the effect on baicalein properties.
Not available
S-EPMC6964663 | biostudies-literature
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