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TranscriptomicsSystematic identification of balanced transposition polymorphisms in Saccharomyces cerevisiae
High-throughput techniques for detecting DNA polymorphisms generally do not identify changes in which the genomic position of a sequence, but not its copy number, varies among individuals. To explore such balanced structural polymorphisms, we used array-based Comparative Genomic Hybridization (aCGH)...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-19 | E-GEOD-14223 | biostudies-arrayexpress
TranscriptomicsYeast m6A methylated mRNAs are enriched on translating ribosomes during meiosis, and under Rapamycin treatment
Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the recent finding of FTO?s (Fat Mass Obesity) N6-methyl-adenosine (m6A) deaminase activity, thus suggested a link between obesity-associated diseases and the presence of m6A...
ORGANISM(S): Saccharomyces cerevisiae SK1 
2015-08-12 | E-GEOD-68435 | biostudies-arrayexpress
TranscriptomicsIntrinsic Coupling of Lagging Strand Synthesis to Chromatin Assembly
We show that ligation-competent Okazaki fragments in Saccharomyces cerevisiae are sized according to the chromatin repeat. Using deep sequencing, we demonstrate that ligation junctions preferentially occur around nucleosome midpoints rather than in internucleosomal linker regions. Disrupting chrom...
ORGANISM(S): Saccharomyces cerevisiae 
2012-02-21 | E-GEOD-33786 | biostudies-arrayexpress
TranscriptomicsMeiotic time-course expression profile
To investigate the dynamics of the meiotic transcriptome and to ensure meiotic synchrony of our samples, we measured RNA abundance in vegetative cells, respiratory (pre-meiotic) cells and in synchronously sporulating cells at various times after transfer to sporulation media (SM). SK1 yeast strain S...
ORGANISM(S): Saccharomyces cerevisiae SK1 
2010-05-22 | E-GEOD-18181 | biostudies-arrayexpress
UnknownRepurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19.
Not available
S-EPMC7247743 | biostudies-literature
TranscriptomicsQuantitative, genome-wide analysis of eukaryotic replication initiation and termination
Via the deep-sequencing of Okazaki fragments from Saccharomyces cerevisiae, we report the first comprehensive documentation of genome-wide replication directionality in any eukaryote; this permits the systematic analysis of both replication initiation and termination. We conduct a genome-wide analys...
ORGANISM(S): Saccharomyces cerevisiae 
2013-02-28 | E-GEOD-40696 | biostudies-arrayexpress
TranscriptomicsMeiosis timecourse expression profile
To investigate transcriptome dynamics during the transition from vegetative growth to meiosis, we measured RNA abundance in vegetative cells (YPD), respiratory cells (pre-meiotic/YPA 8 hours), and in cells undergoing synchronous meiosis/sporulation in the budding yeast Saccharomyces cerevisiae. Ther...
ORGANISM(S): Saccharomyces cerevisiae SK1 
2016-09-01 | E-GEOD-75257 | biostudies-arrayexpress
TranscriptomicsMeiotic time course: open chromatin and expression profile
This SuperSeries is composed of the following subset Series: GSE16163: Meiotic time course of open chromatin as measured by FAIRE GSE18181: Meiotic time course expression profile Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae SK1 
2009-09-25 | E-GEOD-18256 | biostudies-arrayexpress
TranscriptomicsMeiosis timecourse Rap1-depletion expression profile
To investigate the impact of Rap1 binding on nearby gene expression during the transition from vegetative growth to meiosis, we measured RNA abundance in cells depleted (plus doxycycline) or not depleted (minus doxycycline) of Rap1. RNA abundance was measured in depleted and non-depleted condition i...
ORGANISM(S): Saccharomyces cerevisiae SK1 
2016-09-01 | E-GEOD-75259 | biostudies-arrayexpress
TranscriptomicsMeiosis timecourse Rap1 ChIP-chip
To investigate the genome-wide binding dynamics of Rap1 during the transition from vegetative growth to meiosis, we performed Rap1 ChIP-chip experiments in vegetative cells (YPD), respiratory cells (pre-meiotic/YPA 8 hours), and in cells undergoing synchronous meiosis/sporulation in the budding yea...
ORGANISM(S): Saccharomyces cerevisiae SK1 
2016-09-01 | E-GEOD-75261 | biostudies-arrayexpress
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