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TranscriptomicsResponse of Saccharomyces cerevisiae (Dal80M-NM-^T) to linoleic acid hydroperoxide
Oxidative stress is experienced by all aerobic organisms and results in cellular damage. The damage caused during oxidative stress is particular to the oxidant challenge faced, and so too is the induced stress response. The eukaryote Saccharomyces cerevisiae is sensitive to low concentrations of the...
ORGANISM(S): Saccharomyces cerevisiae 
2014-02-13 | E-GEOD-54951 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila developmental time series
Michelle N. Arbeitman, Eileen E. M. Furlong, Farhad Imam, Eric Johnson, Brian H. Null, Bruce S. Baker, Mark A. Krasnow, Matthew P. Scott, Ronald W. Davis and Kevin P. White. Gene Expression During the Life Cycle of Drosophila melanogaster, Science, 297: 2270-2275, 2002. This work can be accessed fro...
ORGANISM(S): Drosophila melanogaster 
2004-11-06 | E-FLYC-6 | biostudies-arrayexpress
TranscriptomicsRNA-Seq profiling of S. Cerevisiae WT BY4741 cells and MOH1-knockout mutants of BY4741 cells (moh1∆) after growth on YPD-Agar for 40 hours
The Yippee-like (YPEL) proteins are a conserved eukaryotic gene family implicated in proliferation, senescence, and stress adaptation. In humans, five paralogs (YPEL1–YPEL5) are widely expressed and encode proteins with high sequence similarity, but the molecular basis of their functions remains poo...
ORGANISM(S): Saccharomyces cerevisiae S288c 
2026-06-15 | E-MTAB-16090 | biostudies-arrayexpress
TranscriptomicsTranscriptional reprogramming of engineered cellobiose-utilizing Saccharomyces cerevisiae in response to cellobiose revealed by RNA-Seq
Saccharomyces cerevisiae cannot metabolize cellobiose in nature. Here, S. cerevisiae was engineered to achieve cellobiose utilization by introducing both a cellodextrin transporter gene (cdt-1) and an intracellular β-glucosidase gene (gh1-1) from Neurospora crassa. We sequenced mRNA from anaerobic e...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-10 | E-GEOD-54825 | biostudies-arrayexpress
TranscriptomicsInfluence of BrpA on critical virulence attributes of Streptococcus mutans
Streptococcus mutans, the primary etiological agent of human dental caries, has developed multiple mechanisms to colonize and form biofilms on the tooth surface. The brpA gene codes for a predicted surface-associated protein with apparent roles in biofilm formation, autolysis, and cell division. In ...
ORGANISM(S): Streptococcus mutans 
2008-08-30 | E-GEOD-11773 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mutations in the yeast TRR1 gene encoding thioredoxin reductase
The Saccharomyces cerevisiae Yap1p transcription factor is required for the H2O2-dependent activation of many antioxidant genes including the TRX2 gene encoding thioredoxin 2. To identify factors that regulate Yap1p activity, we carried out a genetic screen for mutants that show elevated expression ...
ORGANISM(S): Saccharomyces cerevisiae 
2005-06-30 | E-SMDB-2716 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast double aft1aft2 deletion mutant in growth assays
Iron homeostasis in the yeast Saccharomyces cerevisiae is regulated at the transcriptional level by Aft1p, which activates the expression of its target genes in response to low-iron conditions. The yeast genome contains a paralog of AFT1, which has been designated AFT2. To establish whether AFT1 and...
ORGANISM(S): Saccharomyces cerevisiae 
2005-06-29 | E-SMDB-1517 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast population cultured for many generations under conditions to which it is not optimally adapted
This experiment set contains the arrays referenced in Ferea, TL, et al. titled "Systematic changes in gene expression patterns following adaptive evolution in yeast"(Proc Natl Acad Sci USA 1999 96(17):9721-6). A Saccharomyces cerevisiae population was cultured for many generations under conditions ...
ORGANISM(S): Saccharomyces cerevisiae 
2005-06-16 | E-SMDB-98 | biostudies-arrayexpress
GenomicsUncovering novel genetic factors controlling sphingolipid-induced mitochondrial cell death in yeast through genome-wide transposon-insertion mutant screening (SATAY)
Lipid intermediates derived from sphingolipid metabolism are crucial regulators of mitochondrial function from yeast to humans. Among these intermediates, trans-2-hexadecenal (t-2hex) within the sphingolipid degradation pathway exhibits remarkable efficiency in inducing mitochondria-mediated cell de...
ORGANISM(S): Saccharomyces cerevisiae 
2023-08-31 | E-MTAB-13208 | biostudies-arrayexpress
ProteomicsProbing the Sensitivity of the Lumos Mass Spectrometer by analyzing varying amounts of whole cell extracts
PROJECT DESCRIPTION The Orbitrap Fusion Lumos mass spectrometer has recently been shown to have better fragmentation and detection than its predecessors. Previous studies using a HeLa digest analyzed on the Lumos mass spectrometer have reported the number of peptides and proteins identified by rever...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2018-04-19 | MSV000082296 | MassIVE
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