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TranscriptomicsRNA-Seq of human bronchoalveolar lavage and lung biopsy samples in the segmental endotoxin challenge model
Segmental instillation of lipopolysaccharide (LPS) by bronchoscopy can be used as a model to safely induce transient airway inflammation in the human lung. The LPS challenge model enables investigation of cellular mechanisms involved in pulmonary inflammatory processes as well as pharmacodynamic ana...
ORGANISM(S): Homo sapiens 
2024-03-01 | E-MTAB-13318 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human age-dichotomized ER+, N0 breast tumors reveals enhanced NF kappa B and AP-1 activity associated with antiestrogen resistant breast caner
Signaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. In this study, biomarkers co-ordinately up-regulated by NFKB and AP-1 with prognositic si...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7378 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF7 cells following short-term E deprivation, ER-alpha siRNA knockdown and oxidant treatments
To investigate the oxidant sensitivity of E/ER regulated gene expression, E/ER regulated genes are identified using E deprivation or; ER-alpha siRNA knockdown; and oxidative stress responsive is determined by 8hr exposure to diamide, hydrogen peroxide and menadione Experiment Overall Design: MCF7 ce...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-10061 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cystic fibrosis model Cftr knockouts ileum were analysed to investigate intestinal phenotypes
Cystic fibrosis transmembrane conductance regulator (Cftr) knockout mice present the clinical features of low body weight and intestinal disease permitting an assessment of the interrelatedness of these phenotypes in a controlled environment. To identify intestinal alterations which affect body wei...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5715 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung from a mouse model of cystic fibrosis fromB6 and Balb strains vs wild type littermates to determine strain specific differences
Gene expression profiling with microarrays was used to identify genes differentially expressed in the lungs of B6 and BALB CF mice compared to non-CF littermates
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-3100 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human age-dichotomized ER+ breast tumors
To investigate the biological basis between aging and sporadic breast cancer incidence and prognosis, RNA samples from matched ER+ invasive breast cancers diagnosed in either young (â?¤45) or old (â?¥70) women were analyzed by expression microarrays Experiment Overall Design: ER+ breast cancers coll...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8193 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human HepG2 cells treated with false positive genotoxins, true genotoxins and non-genotoxins
In this study we aimed to identify the molecular pathways modified by the false positive genotoxins Quercetin, 8-Hydroxyquinoline and 17beta-Estradiol that may explain their in vitro genotoxic and their in vivo non-genotoxic effects, by combining in vitro transcriptomics with phenotypic data. The ef...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-MEXP-2574 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Clostridium acetobutylicum on glucose and xylose substrates under exponential, continuous and diauxie growth.
Clostridium acetobutylicum was grown in a batch-culture with minimal medium containing glucose and xylose as substrate. Diauxie growth was observed after glucose was consumed. Following the organism grows on xylose. Transcriptional analysis was done to pursue the cellular processes during the switch...
ORGANISM(S): Clostridium acetobutylicum 
2010-09-30 | E-MEXP-2613 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human-melanoma derived cell lines response to chemotherapy
To identify patterns of gene expression that correlate with response to treatment with either melphalan or temozolomide we measured both gene expression using microarray genechips and response to drug using a standard in vitro cell proliferation assay. Senstivity to melphalan was measured 48hrs aft...
ORGANISM(S): Homo sapiens 
2009-02-09 | E-GEOD-10916 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of sympathetic neurons during BMP-induced primary dendritogenesis
The objective of this study was to identify genes that are differentially regulated in cultured sympathetic neurons during BMP-induced dendritic growth and to determine the temporal expression patterns of these genes. We determined that inhibiting transcription within the first 24 hours after adding...
ORGANISM(S): Rattus norvegicus 
2011-06-30 | E-GEOD-28150 | biostudies-arrayexpress
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