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ProteomicsLOSS OF THE BATTEN DISEASE PROTEIN CLN3 LEADS TO MIS-TRAFFICKING OF M6PR AND DEFECTIVE AUTOPHAGIC-LYSOSOMAL REFORMATION
Batten disease, one of the most devastating types of neurodegenerative lysosomal storage disorders, is caused by mutations in CLN3. Here, we show that CLN3 is a vesicular trafficking hub connecting the Golgi and lysosome compartments. Proteomic analysis reveals that CLN3 interacts with several endo-...
ORGANISM(S): Homo sapiens (Human) 
2023-06-20 | PXD031582 | Pride
Human Cln3 Batten Lysosome 
TranscriptomicsProfiling gene expression in HeLa cells following TFEB transient transfection
Total RNA samples from three biological replicates in which TFEB was transiently overexpressed in HeLa cells by transfection using a pcDNA3 vector. As negative control, we used total RNA samples from HeLa cells transfected with an empty pcDNA3 vector. TFEB transfection
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-16267 | biostudies-arrayexpress
ProteomicsTFEB regulates protein synthesis to sustain autophagy during starvation
In response to starvation, cells undergo a metabolic shift to ensure their survival by shutting down protein synthesis and activating catabolic processes, including autophagy, to degrade proteins and recycle nutrients. These processes, however, do require protein synthesis. We asked how this fundame...
ORGANISM(S): Homo sapiens (Human) 
2020-09-30 | PXD016149 | Pride
Human hek293 
UnknownLoss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling
Not available
S-SCDT-10_1038-S44319-025-00613-3 | biostudies-other
ProteomicsLFQ of mNeonGreen-Trap IP-MS from cells expressing TFEB-mNeonGreen
Cells stably expressing TFEB-mNeonGreen proteins were grown in a 10 cm dish and treated with or without LLOMe for 1 h or 3 h, then cross-linked with 0.1% formaldehyde for 10 min at room temperature. After cross-linking was quenched with 100 mM glycine for 4 min at room temperature, cells were washed...
ORGANISM(S): Homo Sapiens (human) 
2025-08-17 | PXD043288 | JPOST Repository
ProteomicsLFQ of mNeonGreen-Trap IP-MS from cells expressing TFEB-mNeonGreen treated with MK6-83
Cells stably expressing TFEB-mNeonGreen proteins were grown in a 10 cm dish and treated with or without MK6-83 for 3 h, then cross-linked with 0.1% formaldehyde for 10 min at room temperature. After cross-linking was quenched with 100 mM glycine for 4 min at room temperature, cells were washed with ...
ORGANISM(S): Homo Sapiens (human) 
2025-08-17 | PXD053327 | JPOST Repository
UnknownTFEB CONTROLS VASCULAR DEVELOPMENT BY REGULATING THE PROLIFERATION OF ENDOTHELIAL CELLS
Not available
S-SCDT-EMBOJ-2017-98250 | biostudies-other
UnknownTFEB AND TFE3 CONTROL GLUCOSE HOMEOSTASIS BY REGULATING INSULIN GENE EXPRESSION.
Not available
S-SCDT-10_15252-EMBJ_2023113928 | biostudies-other
UnknownDrug screening identifies tazarotene and bexarotene as therapeutic agents in Multiple Sulfatase Deficiency
Not available
S-SCDT-10_15252-EMMM_202114837 | biostudies-other
UnknownLight-responsive microRNA miR-211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance
Not available
S-SCDT-EMBOJ-2019-102468 | biostudies-other
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