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TranscriptomicsGenetic architecture of murine skin inflammation and tumor susceptibility
Gene expression in self-renewing epithelial tissues is controlled by cis- and trans-activating regulatory factors that mediate responses to exogenous agents capable of causing tissue damage, infection, inflammation, or tumorigenesis. We used network construction methods to analyze the genetic archi...
ORGANISM(S): Mus musculus 
2008-12-31 | E-GEOD-12248 | biostudies-arrayexpress
TranscriptomicsProgressive genomic instability in the FVB/KrasLA2 mouse model of lung cancer
Alterations in DNA copy number contribute to the development and progression of cancers and are common in epithelial tumors. We have used array Comparative Genomic Hybridization (aCGH) to visualize DNA copy number alterations across the genomes of lung tumors in the KrasLA2 model of lung cancer. C...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-29230 | biostudies-arrayexpress
TranscriptomicsExpression analysis of superior cervical ganglion from backcrossed TH-MYCN transgenic mice
Neuroblastoma susceptibility in TH-MYN mice is heavily influence by mouse strain background. We have combined linkage analysis of tumor susceptibility with expression QTL analysis of superior cervical ganglia (pure peripheral symptathetic nervous tissue) to identify genes underlying tumor formation...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-59675 | biostudies-arrayexpress
UnknownA subset of skin tumor modifier loci determines survival time of tumor-bearing mice.
Not available
S-EPMC24768 | biostudies-literature
TranscriptomicsMurine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes
We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated Trp53 null mammary tissue to sham or irradiated hosts. Gene expression profiles of tumors that arose in irradiated mice are distinct from those that arose in naM-CM-/ve hosts. Host irradiation in...
ORGANISM(S): Mus musculus 
2013-04-04 | E-GEOD-42742 | biostudies-arrayexpress
TranscriptomicsIdentification of Hipk2 as a central regulator of white fat development
Homeodomain interacting protein kinase 2 (Hipk2) has previously been implicated in control of several transcription factors involved in embryonic development, apoptosis, cell proliferation and tumour development1–3. Analysis of gene expression in tissues from genetically heterogeneous mouse or human...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-46077 | biostudies-arrayexpress
TranscriptomicsNetwork Analysis of Skin Tumor Progression Identifies a Rewired Genetic Architecture Affecting Inflammation and Tumor Susceptibility (aCGH)
Background: Germline polymorphisms can influence gene expression networks in normal mammalian tissues and can affect disease susceptibility. We and others have shown that analysis of this genetic architecture can identify single genes and whole pathways that influence complex traits including inflam...
ORGANISM(S): Mus musculus 
2010-12-23 | E-GEOD-26273 | biostudies-arrayexpress
UnknownPediatric sleep movements: a review of methodologies, normative data, disease associations, and research gaps.
Not available
S-EPMC12493083 | biostudies-literature
UnknownManipulative therapy and/or NSAIDs for acute low back pain: design of a randomized controlled trial [ACTRN012605000036617].
Not available
S-EPMC1298305 | biostudies-literature
UnknownA susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice.
Not available
S-EPMC11338061 | biostudies-literature
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