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UnknownClinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.
Not available
S-EPMC5570190 | biostudies-literature
ProteomicsMolecular analysis of brain tumour models
Pilocytic astrocytomas and other paediatric low-grade gliomas (pLGGs) are often considered single-pathway diseases due to the predominance of MAPK/ERK pathway alterations observed in these patients. However, emerging evidence suggests that the MAPK/ERK interacts within a complex signalling network t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD060246 | Pride
Kiaa1549 Label-free proteomics Mapk Braf Plgg Phosphoproteomics Fgfr Lc-ms/ms 
UnknownGene expression profiling of 151 pediatric low-grade gliomas
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-60898 | biostudies-other
TranscriptomicsGene expression profiling of 151 pediatric low-grade gliomas
We performed gene expression profiling on 151 paraffin-embedded PLGGs from different locations, ages, histological subtypes as well as BRAF genetic status We also compared molecular differences to normal pediatric brain expression profiles to observe whether those patterns were mirrored in normal br...
ORGANISM(S): Homo sapiens 
2014-08-29 | E-GEOD-60898 | biostudies-arrayexpress
TranscriptomicsMYBQKI overexpression in mouse NSC, and suppression of wild type Qk
Samples are mouse neural stem cells overexpressing eGFP, MYBtr, MYBQKI5, MYBQKI6 and MYBQKI6 with suppression of Qk (or LacZ) We overexpressed MYBQKI in mouse NSC, and then also suppressed wild type QKI in some samples
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-75796 | biostudies-arrayexpress
GenomicHuman Pilocytic Astrocytoma Single Cell RNA Sequencing

Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement. Here, we perform scRNAseq in six PAs using methods that enabled detection of the rearrangement. When compared to higher-grade gliomas, a strikingly higher proportion o...

phs001854 | dbGaP
TranscriptomicsEWS/WT1 co-operates with the loss of p53 to exert its oncogenic effects and up-regulates canonical Wnt pathway signaling.
The t(11;22)(p13;q12) translocation is pathognomonic for the highly aggressive desmoplastic small round cell tumour (DSRCT). The translocation fuses exon 7 of the EWS gene to exon 8 of the WT1 gene (EWS/WT1). Two splice variants of EWS/WT1 exist, arising from the presence (+KTS) or absence (-KTS) of...
ORGANISM(S): Mus musculus 
2014-11-01 | E-GEOD-42649 | biostudies-arrayexpress
GenomicGenomic Characterization of Pediatric Low-Grade Gliomas

Pediatric low-grade gliomas (PLGGs) are the most common pediatric brain-tumor, with more than ten histologic subtypes recognized by the World Health Organization. We performed a genomic analysis of 230 PLGGs of which 73 had whole genome/RNA sequencing performed and show that MYB-QKI fusions defin...

phs001054 | dbGaP
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