Sort   by:  
 Page size 
TranscriptomicsFGFR signature
Drugs that target specific gene alterations have proven beneficial in the treatment of cancer. Because cancer cells have multiple resistance mechanisms, it is important to understand the downstream pathways of the target genes and monitor the pharmacodynamic markers associated with therapeutic effic...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-73024 | biostudies-arrayexpress
ProteomicsIntegrative analysis of Multi-omics data of FGFR inhibitor
Dissection of the mechanism of action of FGFR inhibitor by multi-omic analysis
ORGANISM(S): Homo Sapiens 
2025-02-05 | PXD060496 |
TranscriptomicsTranscription profiling by array of breast cancer cell lines and correlations with fibroblast growth factor receptor (FGFR) signalling and repression
Baseline gene expression profiling of breast cancer cell lines and correlations with FGFR signalling and repression
ORGANISM(S): Homo sapiens 
2011-12-01 | E-MTAB-879 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of PNT1a prostate cells expressing FGFR-4 Arg388 or Gly388.
We have shown that in PNT1a cells expressing exogenous FGFR4 Arg388 or Gly388 under the control of the EF1 promoter almost all FGFR signaling can be attributed to the transfected receptor, and the two FGFR-4 isoforms are expressed at equivalent levels in the two cell lines. Furthermore, we have show...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-20906 | biostudies-arrayexpress
TranscriptomicsHeparan Sulfation Dependent FGF Signalling Maintains ES Cells Primed for Differentiation in a Heterogeneous State
Embryonic stem (ES) cells continuously decide whether to maintain pluripotency or differentiate. While exogenous LIF and BMP4 perpetuate a pluripotent state, less is known about factors initiating differentiation. We show that heparan sulfate (HS) proteoglycans are critical co-receptors for signals ...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-15974 | biostudies-arrayexpress
ModelsEGFR-FGFR SIGNALLING
EGFR, FGFR and TNFR signaling in NSCLC.
2026-06-27 | MODEL2606190001 | BioModels
TranscriptomicsCharacterising the cellular activity of new Fibroblast Growth Factor Receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance.
Fibroblast growth factor receptors (FGFRs) can act as driving oncoproteins in certain cancers due to mutation, over-expression or activating gene fusions and are therefore attractive drug targets. Here we have characterized tumour cell responses to three new inhibitors of FGFR1-3, AZ12576089, AZ129...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-TABM-1222 | biostudies-arrayexpress
ProteomicsThe phosphatase PTPRG controls FGFR1 activity and influences sensitivity to FGFR kinase inhibitors
Recently, FGFR1 has been found to be overexpressed in osteosarcoma and thus represents an important target for precision medicine. However, because targeted cancer therapy based on FGFR inhibitors has so far been less efficient than expected, a detailed understanding of the target is important. We h...
ORGANISM(S): Homo sapiens (Human) 
2018-01-29 | PXD006157 | Pride
Protein interaction Mass spectrometry Ptprg Fgfr1 
TranscriptomicsA receptor tyrosine kinase network comprised of FGFRs, EGFR, ERBB2, and MET drives growth and survival of HNSCC cell lines.
We have previously shown that some gefitinib insensitive head and neck squamous cell carcinoma (HNSCC) cell lines exhibit dominant autocrine fibroblast growth factor receptor (FGFR) signaling. Herein, we deployed a whole genome loss-of-function screen to identify genes whose knockdown potentiated th...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-39305 | biostudies-arrayexpress
TranscriptomicsIn vitro expression in FGFR inhibitor sensitive and resistant cell lines
The challenge of developing effective pharmacodynamic biomarkers for pre-clinical and clinical testing of FGFR signalling inhibition is significant. Assays that rely on the measurement of phospho-protein epitopes can be limited by the availability of effective antibody detection reagents. Transcript...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-MTAB-4749 | biostudies-arrayexpress
Sort   by:  
 Page size