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ProteomicsN-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and the nuclear envelope
Fibroblast growth factor receptor 1 (FGFR1) is a heavily N-glycosylated cell surface receptor tyrosine kinase, which in conjunction with fibroblast growth factors (FGFs) transmits signals through the plasma membrane. The balanced FGF/FGFR1 signaling is crucial for the development and homeostasis of ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042325 | Pride
Fgfr1 Trafficking Glycosylation Label-free Nucleus Signaling 
TranscriptomicsZMYM2/FGFR1, BCR/FGFR1 or BCR/ABL1 in human cord blood CD34+ cells reveals similar but distinct gene expression profiles
The 8p11 myeloproliferative syndrome (EMS), also referred to as the stem cell leukemia/lymphoma syndrome, is a chronic myeloproliferative disorder that rapidly progresses into an acute leukemia. Molecularly, EMS is characterized by fusion of various partner genes to the FGFR1 gene, resulting in cons...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-15811 | biostudies-arrayexpress
TranscriptomicsFGFR1 target genes in brown adipose tissues
We aimed to identify genes that are regulated by FGFR1 in brown adipose tissues of adult male ob/ob mice by injecting 1 mg/kg anti-FGFR1 agonistic antibody. Brown adipose tissues were isolated from adult male ob/ob mice at day 4 after a single intraperitoneal injection of 1 mg/kg anti-FGFR1 agonisti...
ORGANISM(S): Mus musculus 
2012-01-06 | E-GEOD-32316 | biostudies-arrayexpress
TranscriptomicsRNA sequencing data for knockdown of FGFR1 in TR-T47D cells
FGFR1 is upregulated in a proportion of luminal breast cancer. This experiment investigates the role of FGFR1 in activating the cGAS-STING pathway. Data include RNA sequencing of the tamoxifen-resistant T47D (TR-T47D) cell line after knock down by short hairpin RNA with and without treatment with t...
ORGANISM(S): Homo sapiens 
2026-08-17 | E-MTAB-17490 | biostudies-arrayexpress
ProteomicsThe phosphatase PTPRG controls FGFR1 activity and influences sensitivity to FGFR kinase inhibitors
Recently, FGFR1 has been found to be overexpressed in osteosarcoma and thus represents an important target for precision medicine. However, because targeted cancer therapy based on FGFR inhibitors has so far been less efficient than expected, a detailed understanding of the target is important. We h...
ORGANISM(S): Homo sapiens (Human) 
2018-01-29 | PXD006157 | Pride
Protein interaction Mass spectrometry Ptprg Fgfr1 
ProteomicsRAPID RESISTANCE TO BET INHIBITORS IS MEDIATED BY FGFR1 IN GLIOBLASTOMA
Bromodomain and extra-terminal domain (BET) proteins are therapeutic targets in several cancers including the most common malignant adult brain tumor glioblastoma (GBM). Multiple small molecule inhibitors of BET proteins have been utilized in preclinical and clinical studies. Unfortunately, BET inhi...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043214 | Pride
Fgfr1 Glioblastoma Bet inhibitor 
ProteomicsActivation of CD44 / AKT signaling promotes resistance to FGFR1 inhibition in squamous cell lung cancer
Lung cancer is the leading cause of cancer related deaths, worldwide. Fibroblast growth factor receptor 1 (FGFR1) gene amplification is one of the most prominent and potentially targetable genetic alterations in squamous cell lung cancer (SQCLC). Highly selective tyrosine kinase inhibitors have been...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD025389 | Pride
Cd44 Akt Mass spectrometry Phosphoproteomics Lung cancer Fgfr1 
TranscriptomicsTranscription profiling by array of prostate from mice at different stages of JOCK1 prostate cancer progression to identify FGFR1-mediated gene expression changes
FGFR1 mediated changes in gene expression at different stages of JOCK1 prostate cancer progression JOCK1 mice which express a prostate localize inducible version of the FGFR1 gene (iFGFR1) were used to determine what are the changes in gene expression at distinct stages of JOCK1 tumor progression. ...
ORGANISM(S): Mus musculus 
2008-03-04 | E-MEXP-1296 | biostudies-arrayexpress
GenomicsGenome-wide binding profiles of nuclear FGFR1, RXR? and Nur77 in pluripotent mouse Embryonic Stem Cells and during Retinoic Acid-induced differentiation
We report the genome-wide binding patterns of nuclear FGFR1, RXR? and Nur77 in pluripotenet mESC and as mESC differentiate towared a neuronal lineage in response to high levels of Retinoic Acid treatment in vitro. We also report the genome-wide incorporation of histone varant H3.3 into chromatin spe...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-65695 | biostudies-arrayexpress
ProteomicsDiverse Fgfr1 signaling pathways and endocytic trafficking regulate early mesoderm development
The Fibroblast growth factor (FGF) pathway is a conserved signaling pathway required for embryonic development. Activated FGF receptor 1 (FGFR1) drives multiple intracellular signaling cascade pathways, including ERK/MAPK and PI3K/AKT, collectively termed canonical signaling. However, unlike Fgfr1 n...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD050632 | Pride
Fgf  mesoderm development  kidney development  cell signaling  cell adhesion  endocytic trafficking 
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