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TranscriptomicsTranscriptomic characterization of a virulence-deficient phosphatidylcholine-negative Agrobacterium tumefaciens mutant
To learn more about the global effects of phosphatidylcholine (PC)-deficiency in A. tumefaciens, we performed transcriptomic studies comparing the wild type and a PC-deficient DpmtA Dpcs mutant. We expanded the number of affected virulence genes and showed that the loss of PC was correlated with alt...
ORGANISM(S): Agrobacterium tumefaciens str. C58 
2010-04-07 | E-GEOD-21223 | biostudies-arrayexpress
ProteomicsSame same but different – The global response of Escherichia coli to five different LpxC inhibitors
A promising but yet clinically unexploited antibiotic target in difficult-to-treat Gram-negative bacteria is LpxC, the key enzyme in the biosynthesis of lipopolysaccharides (LPS), which are the major constituents of the outer membrane. To gain insights into the mode of action of five different LpxC ...
ORGANISM(S): Escherichia coli 
2024-06-16 | PXD043195 | Pride
Lipopolysaccharide Lps Antibiotics Phospholipid Outer membrane Ftsh 
ProteomicsInterspecies comparison of the bacterial response to allicin reveals species-specific defense strategies
Allicin, a volatile diallylthiosulfinate from garlic (Allium sativum), exhibits broad-spectrum activity against microbial pathogens. It disrupts thiol and redox homeostasis, proteostasis, and cell membrane integrity leading to inactivation of even multidrug resistant strains. Since medicine demands ...
ORGANISM(S): Pseudomonas aeruginosa PAO1 Bacillus subtilis subsp. subtilis str. 168 
2021-03-09 | PXD012622 | Pride
Mode of action Proteomic response Bacillus subtilis Allicin Pseudomonas aeruginosa 
ProteomicsIonophore 4-Br-A23187 causes copper stress in B. subtilis
Ionophores are small molecules or peptides that transport metal ions across biological membranes. Their transport capabilities are typically characterized in vitro using vesicles and single ion species. It is difficult to infer from these data which effects ionophores have on living cells in a compl...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2022-06-08 | PXD028938 | Pride
4-br-a23187 Antibiotic Ionophore Bacillus subtilis Copper 
ProteomicsApplicability of chromatographic co-elution for antibiotic research
Identification of the molecular target is crucial for evaluating novel antibiotics. To support target identification, a label-free method based on chromatographic co-elution (TICC) has been developed previously. In TICC, an alteration in the elution profile of the target-bound drug compared to free ...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2020-10-01 | PXD017640 | Pride
Essential proteins Bacillus subtilis Protein complexes Protein-protein interaction 
ProteomicsProteome profiling of Rhodobacter capsulatus wild type and a ΔmodABC mutant in response to molybdenum
The diazotrophic bacterium Rhodobacter capsulatus is able to synthesize two nitrogenases, a molybdenum-dependent and an alternative Mo-free iron-only nitrogenase, enabling growth with molecular dinitrogen (N2) as sole nitrogen source. The Mo response of the wild type and a mutant lacking the high-af...
ORGANISM(S): Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) 
2015-12-14 | PXD003123 | Pride
Rhodobacter capsulatus molybdenum lc-ms proteomics mse 
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