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GenomicsDiabetes induced microbiome dysbiosis is associated with therapy resistance in Pancreatic Ductal Adenocarcinoma (PDAC)
Pancreatic cancer is the 3rd most prevalent cause of cancer related deaths in United states alone, with over 55000 patients being diagnosed in 2019 alone and nearly as many succumbing to it. Late detection, lack of effective therapy and poor understanding of pancreatic cancer systemically contribute...
ORGANISM(S): mouse gut metagenome 
2020-11-30 | E-MTAB-8739 | biostudies-arrayexpress
GenomicsMicrobial changes in early pancreatic cancer progression
Pancreatic cancer is among the deadliest cancers that affects almost 54,000 patients in United States alone, with 90% of them succumbing to the disease. Lack of early detection is considered to be the foremost reason for such dismal survival rates. Our study shows that resident gut microbiota is alt...
ORGANISM(S): mouse gut metagenome 
2019-07-07 | E-MTAB-6921 | biostudies-arrayexpress
TranscriptomicsZebrafish foxc1a is required for appendage specific neural circuit development
RNA-seq analysis of zebrafish foxc1a mutant For RNA-seq, mRNA was extracted from 38-40 hpf old embryos. We isolated wild type and foxc1a mutant samples by dissecting the entire first 6 anterior somitic segments (AS) through which the fin nerves migrate, and the adjacent posterior segments (PS; segme...
ORGANISM(S): Danio rerio 
2015-03-05 | E-GEOD-64125 | biostudies-arrayexpress
UnknownOxygen-depleted and ferruginous seawater composition imprinted in Early Cretaceous Fe-rich Al-glauconites in marginal marine deposits.
Not available
S-EPMC12552670 | biostudies-literature
TranscriptomicsEffects of HIV infection and opioids on gut microbiota
Opioid use is associated with worse outcome in HIV-infected patients. The exacerbated disease progression by opioids is mainly driven by increased epithelial damage and less regenerative response. The present study investigates how opioids potentiate HIV disease progression by impairing intestinal e...
ORGANISM(S): Mus musculus 
2020-01-11 | E-MTAB-7883 | biostudies-arrayexpress
GenomicsOpioid-induced gut microbial disruption leads to gut barrier compromise and sustained systemic inflammation.
Morphine and its pharmacological derivatives are the most prescribed analgesics for moderate to severe pain management. However, chronic use of morphine reduces pathogen clearance and induces bacterial translocation across the gut barrier. The enteric microbiome has been shown to play a critical rol...
ORGANISM(S): Mus musculus domesticus 
2016-06-01 | E-MTAB-3722 | biostudies-arrayexpress
GenomicsEffect of morphine treatment on microbiome in the context of microbial transplant.
Morphine causes microbial dysbiosis. In this study we focused on restoration of native microbiota in morphine treated mice and looked at the extent of restoration and immunological consequences of this restoration. Fecal transplant has been successfully used clinically, especially for treating C. di...
ORGANISM(S): Mus musculus domesticus 
2016-06-01 | E-MTAB-3723 | biostudies-arrayexpress
GenomicsAge associated differences in microbiome in Rhesus Macaque
Aging is associated with declining immunity and inflammation as well as alterations in the gut microbiome with a decrease of beneficial microbes and increase in pathogenic ones. The aim of this study was to investigate aging associated gut microbiome in relation to immunologic and metabolic profile ...
ORGANISM(S): gut metagenome 
2022-02-01 | E-MTAB-10160 | biostudies-arrayexpress
UnknownDifferential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis.
Not available
S-EPMC4759540 | biostudies-literature
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