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ProteomicsComparative Proteomic Signatures in Periodontitis: Saliva, Gingival Crevicular Fluid (GCF), Plaque, vs. Serum
Saliva, gingival crevicular fluid (GCF), and serum are common sources for studying host response and oral microbiota in periodontal patients. This cross-sectional study aimed to compare the proteomic signatures of periodontitis patients using full-mouth periodontal sampling with those obtained from...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD055509 | Pride
Gcf Serum Saliva Periodontitis 
ProteomicsA. aphrophilus uses a type VI secretion system to modify epithelial cell responses to highly leukotoxic A. actinomycetemcomitans
The Type VI secretion system (T6SS) is a bacterial mechanism that delivers effectors to eliminate competitors and modulate host responses. We previously discovered that the oral symbiont Aggregatibacter aphrophilus uses its T6SS to kill the pathobiont Aggregatibacter actinomycetemcomitans. To unders...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD057672 | Pride
A. aphrophilus A. actinomycetemcomitans T6ss 
ProteomicsProteomic analysis of Filifactor alocis type and clinically isolated strains
Filifactor alocis is a Gram-positive asaccharolytic, obligate anaerobic rod of the phylum Firmicutes, strongly associated with periodontitis. In this study, we performed the whole proteomic analysis of an F. alocis type strain (ATCC 35896; CCUG 47790), as well as nine clinically isolated strains at ...
ORGANISM(S): Filifactor alocis 
2022-06-09 | PXD026971 | Pride
Clinically isolated strains Filifactor alocis 
ProteomicsPCT-assisted mass spectrometric quantification of gingival tissue reveals dynamics of protein synthesis during initiation and progression of inflammatory disease
Understanding the progression of periodontal destruction is at the forefront of periodontal research. Therefore, we aimed to capture the dynamics of gingival tissue proteome during initiation and progression of an experimental periodontitis developed by placing silk ligatures on the second molars of...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-09 | PXD014608 | Pride
Experimental periodontitis Gingival tissue Pressure cycling technology Label-free quantitation Proteome Gingival inflammation Periodontitis Pct 
ProteomicsProteome mapping of human gingival tissue in health and disease
Gingival tissue proteome is at the forefront of the periodontal research, yet have been hampered by lack of sufficient tissue-extraction methods. Using an emerging technology for tissue homogenization, pressure cycling technology (PCT), we characterize the gingival tissue proteomic profiles of both ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-25 | PXD018029 | Pride
Pressure cycling technology Gingival tissue proteome Chronic periodontitis 
ProteomicsHistone-like family of nucleoid structuring protein of A. actinomycetemcomitans promotes biofilm formation and alters protein dynamics of other species within multi-species biofilm
Aggregatibacter actinomycetemcomitans is a Gram-negative organism, strongly associated with aggressive forms of periodontitis. An important virulence property of A. actinomycetemcomitans is its ability to form tenacious biofilms that can attach to abiotic as well as biotic surfaces. The histone-like...
ORGANISM(S): Candida albicans (Yeast) Aggregatibacter aphrophilus Streptococcus mutans Streptococcus oralis Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) Fusobacterium nucleatum Veillonella dispar Actinomyces oris 
2018-06-05 | PXD008444 | Pride
Multi-species biofilm Hns A. actinomycetemcomitans Label-free quantification 
ProteomicsBacterial symbionts use a type VI secretion system for fitness increase against pathobionts
The Type VI Secretion System (T6SS) in bacteria is a versatile mechanism that facilitates protein transport into neighboring cells and can act as an antibacterial weapon by eliminating competing organisms in the vicinity. The objective of this study was to characterize the T6SS in Aggregatibacter ap...
ORGANISM(S): Candida albicans (Yeast) Streptococcus mutans Aggregatibacter aphrophilus Streptococcus oralis Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) Fusobacterium nucleatum subsp. nucleatum Veillonella dispar Actinomyces oris 
2024-05-24 | PXD042723 | Pride
Aggregatibacter actinomycetemcomitans T6ss Aggregatibacter aphrophilus 
ProteomicsLabel-free quantitative proteomics versus antibody-based assays to measure neutrophil derived enzymes in saliva
Discovery-based quantitative proteomics identified dozens of novel protein candidates in saliva, yet none are clinically qualified. Mass spectrometry (MS) has been recognized as newer 'gold standard' for the identification and analysis of individual proteins in complex biological samples due to high...
ORGANISM(S): Homo sapiens (Human) 
2019-12-20 | PXD015220 | Pride
Saliva Huamn experimental gingivitis 
ProteomicsGingival exudatome dynamics implicates inhibition of the alternative complement pathway in the protective action of the C3 inhibitor Cp40 in non-human primate periodontitis
Complement inhibition has been successfully used to treat periodontitis in animal models. However, proteome studies that investigated the role of complement C3 were missing. The objective of this study was to characterize local tissue exudate (“gingival crevicular fluid”; GCF) changes after administ...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2018-08-17 | PXD009502 | Pride
C3 inhibitor Gcf Periodontitis Macaca fascicularis 
ProteomicsA proteomic investigation of the dorsal muscle in Tibetan sheep
Firstly, the back muscle samples of Tibetan sheep of the same age were collected for subsequent proteomic analysis. The integrated and analyzed results aimed to identify proteins and pathways associated with meat quality and growth regulation in sheep, thereby providing a theoretical foundation for...
ORGANISM(S): Ovis Aries 
2024-07-26 | PXD054235 |
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