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ProteomicsTherapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability
Tumor cells must rewire nucleotide synthesis to satisfy the demands of unbridled proliferation. Meanwhile, they exhibit augmented reactive oxygen species (ROS) production which paradoxically damages DNA and free dNTPs. How these metabolic processes are integrated to fuel tumorigenesis remains to be ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-27 | PXD043444 | Pride
Myc Plk1 Nudt1 Cancer，protac 
UnknownOsCPK12 phosphorylates OsCATA and OsCATC to regulate H2O2 homeostasis and improve oxidative stress tolerance in rice.
Not available
S-EPMC10943579 | biostudies-literature
UnknownImpact of skin capsular distance on the performance of controlled attenuation parameter in patients with chronic liver disease.
Not available
S-EPMC5023997 | biostudies-literature
UnknownCharacterization of the Complete Mitochondrial Genome of Basidiomycete Yeast Hannaella oryzae: Intron Evolution, Gene Rearrangement, and Its Phylogeny.
Not available
S-EPMC8193148 | biostudies-literature
ProteomicsComparative proteomic analysis of porcine serum between experimental and control groups
This project contains LC-MS/MS-based proteomic data generated from porcine serum samples. Protein identification and quantitative analyses were performed to characterize the serum proteome and investigate differential protein expression among experimental groups.
ORGANISM(S): Sus Scrofa Domesticus 
2026-06-22 | PXD079982 |
UnknownHelicobacter hepaticus CdtB Triggers Colonic Mucosal Barrier Disruption in Mice via Epithelial Tight Junction Impairment Mediated by MLCK/pMLC2 Signaling Pathway.
Not available
S-EPMC11860670 | biostudies-literature
UnknownIncreased glutamic acid decarboxylase expression in the hypothalamic suprachiasmatic nucleus in depression.
Not available
S-EPMC5686266 | biostudies-literature
UnknownMiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats.
Not available
S-EPMC6826124 | biostudies-literature
UnknownTherapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability.
Not available
S-EPMC10944511 | biostudies-literature
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
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