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ProteomicsAfBPP of Navtemadlin probes in MCF-7 cells
Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. The selectivity of this molecule is poorly understood. So we synthesised and validated two photoactivatable clickable probes...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD058036 | Pride
Navtemadlin Mcf-7 Afbpp 
ProteomicsAfBPP of Navtemadlin probes in SJSA-1 cells
Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. The selectivity of this molecule is poorly understood. So we synthesised and validated two photoactivatable clickable probes...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD058033 | Pride
Navtemadlin Sjsa-1 Afbpp 
ProteomicsWhole proteome time course experiment in MCF-7 cells
Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. In this experiment, we test the effect of Navtemadlin treatment on protein expression in MCF-7 cells over the course of 24 h...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD058054 | Pride
Whole proteome Mcf-7 Time-course 
ProteomicsWhole proteome time course experiment in SJSA-1 cells
Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. In this experiment, we test the effect of Navtemadlin treatment on protein expression in SJSA-1 cells over the course of 24 ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD058053 | Pride
Whole proteome Time course Sjsa-1 
ProteomicsComparison of SJSA-1 and MCF-7 whole proteome after Navtemadlin treatment
Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. In this experiment, we compare the whole proteme of MCF-7 and SJSA-1 cells following Navtemadlin treatment in order to gain ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD058081 | Pride
Whole proteome Navtemadlin Sjsa-1 Mcf-7 
ProteomicsWhole proteome experiment to validate treatment conditions in MCF-7 cells
Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. The selectivity of this molecule is poorly understood. So we synthesised and validated two photoactivatable clickable probes...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD058050 | Pride
Whole proteome Navtemadlin Mcf-7 
UnknownDivergence in female damselfly sensory structures is consistent with a species recognition function but shows no evidence of reproductive character displacement.
Not available
S-EPMC6303706 | biostudies-literature
UnknownRacial And Ethnic Disparities In Pandemic-Era Unemployment Insurance Access: Implications For Health And Well-Being.
Not available
S-EPMC10353345 | biostudies-literature
ProteomicsWhole proteome experiment to validate treatment conditions in SJSA-1 cells
Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. The selectivity of this molecule is poorly understood. So we synthesised and validated two photoactivatable clickable probes...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD058047 | Pride
Sjsa-1 Whole proteome Navtemadlin 
ProteomicsAfBPP of pyrrolopyrimidine α-helix mimetics
A wide range of small molecule scaffolds capable of mimicking protein α-helices to modulate protein-protein interactions have been reported, yet their target selectivity is poorly understood. Here, we report the affinity-based protein profiling of three structurally distinct classes of α-helix mimet...
ORGANISM(S): Homo sapiens (Human) 
2026-08-05 | PXD063432 | Pride
Affinity-based protein profiling Α-helix mimetics Pyrrolopyrimidine Mdm2 
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