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ProteomicsSubstantial Influence of ERAP2 on the HLA-B*40:02 peptidome. Implications for HLA-B*27-negative ankylosing spondylitis.
HLA-B*40:02 is one of a few Major Histocompatibility Complex class I (MHC-I) molecules associated with ankylosing spondylitis (AS) independently of HLA-B*27. The endoplasmic reticulum aminopeptidase 2 (ERAP2), an enzyme that process MHC-I ligands and preferentially trims N-terminal basic residues, i...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD014804 | Pride
Hla-b*40:02 peptidome Hla-b*27 Ankylosing spondylitis Erap2 
ProteomicsRedundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behçet’s Disease-Associated HLA-B*51 Peptidome
The endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 trim peptides to be loaded onto HLA molecules, including the main risk factor for Behçet’s disease HLA-B*51. ERAP1 is also a risk factor among HLA-B*51-positive individuals, whereas no association is known with ERAP2. This study addressed the...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD012348 | Pride
Hla-b*51 Erap1 Behçet’s disease Erap2 Peptidome 
ProteomicsEditing the immunopeptidome of melanoma cells using a potent inhibitor of ER aminopeptidase 1
The efficacy of cancer immunotherapy, including treatment with immune-checkpoint inhibitors, is often limited by ineffective presentation of antigenic peptides that can elicit T-cell mediated anti-tumor cytotoxic responses. Therefore, manipulating antigen presentation is an emerging approach for enh...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD011766 | Pride
Inhibitor Immunopeptidome Erap1 
ProteomicsAllele-specific alterations in the peptidome underlie the joint association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy
Birdshot chorioretinopathy (BSCR) is a rare inflammatory eye disease very strongly associated with HLA-A*29:02, with >95% of patients carrying this allele. BSCR is also associated with endoplasmic reticulum aminopeptidase (ERAP)2, an enzyme involved in processing HLA class I ligands. We analyzed the...
ORGANISM(S): Homo sapiens (Human) 
2018-05-17 | PXD007679 | Pride
Hla-a*29:02 Endoplasmic reticulum aminopeptidase 2 (erap2) Birdshot chorioretinopathy 
ProteomicsThe Behçet’s Disease associated Hap10 variant of ERAP1 generates a low affinity HLA-B*51 peptidome through differential processing of two subpeptidomes
HLA-B*51, the main risk factor for Behçet’s disease (BD), binds two main subpeptidomes consisting of low affinity peptides with Ala as their second amino acid and higher affinity peptides with Pro at this position. A low activity variant of ERAP1, Hap10, is uniquely associated with BD susceptibility...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006215 | Pride
Behçet's disease Erap1 Hla-b*51 Antigen processing 
Proteomics,MultiomicsHLA peptides (LC-MSMS) induced by Decitabine in Glioblastoma cell lines
Treatment of cancer cells with anti-cancer drugs often fails to achieve complete remission. Yet, such drug treatments may induce alteration in the tumor’s gene expression patterns, including those of Cancer/Testis Antigens (CTA). The degradation products of such antigens can be presented as HLA pept...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080843 | MassIVE
ProteomicsThe effect of interferons on presentation of defective ribosome products as HLA peptides
The class I major histocompatibility complex (MHC) bound peptides, produced from immature proteins that are degraded rapidly are called defective ribosome products (DRiPs). Such DRiPs are possibly involved with early alerting of the immune system about impeding infections, thus bringing about faster...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-25 | MSV000096209 | MassIVE
TranscriptomicsHLA peptides derived from tumor antigens induced by inhibition of DNA methylation for development of drug-facilitated immunotherapy
Treatment of cancer cells with anti-cancer drugs often fails to achieve complete remission. Yet, such drug treatments may induce alteration in the tumor’s gene expression patterns, including those of Cancer/Testis Antigens (CTA). The degradation products of such antigens can be presented as HLA pe...
ORGANISM(S): Homo sapiens 
2016-07-19 | E-GEOD-80137 | biostudies-arrayexpress
ProteomicsIdentification of tumor antigens among the HLA peptidomes of Glioblastoma tumors and plasma
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. F...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084343 | MassIVE
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