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ProteomicsAllele-specific alterations in the peptidome underlie the joint association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy
Birdshot chorioretinopathy (BSCR) is a rare inflammatory eye disease very strongly associated with HLA-A*29:02, with >95% of patients carrying this allele. BSCR is also associated with endoplasmic reticulum aminopeptidase (ERAP)2, an enzyme involved in processing HLA class I ligands. We analyzed the...
ORGANISM(S): Homo sapiens (Human) 
2018-05-17 | PXD007679 | Pride
Hla-a*29:02 Endoplasmic reticulum aminopeptidase 2 (erap2) Birdshot chorioretinopathy 
ProteomicsERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29
Birdshot Uveitis (BU) is a blinding inflammatory eye condition that only affects HLA-A29-positive individuals. Genetic association studies linked ERAP2 with BU, an aminopeptidase which trims peptides before their presentation by HLA class I at the cell surface, which suggests that ERAP2-dependent pe...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024109 | Pride
Hla-a29 Birdshot Erap2 Autoimmunity Immunopeptidome 
ProteomicsAn ERAP2 inhibitor induces cell-surface presentation of many new and potentially antigenic peptides by cancer cells
Recent studies have linked the activity of ER aminopeptidase 2 (ERAP2) to increased efficacy of immune-checkpoint inhibitor cancer immunotherapy, suggesting that pharmacological inhibition of ERAP2 could have important therapeutic implications. To explore the effects of ERAP2 inhibition on the immun...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD029895 | Pride
Inhibitor Dg011a Mhci Molt4 Er aminopeptidase 2 Erap2 Immunopeptidomics 
ProteomicsSubstantial Influence of ERAP2 on the HLA-B*40:02 peptidome. Implications for HLA-B*27-negative ankylosing spondylitis.
HLA-B*40:02 is one of a few Major Histocompatibility Complex class I (MHC-I) molecules associated with ankylosing spondylitis (AS) independently of HLA-B*27. The endoplasmic reticulum aminopeptidase 2 (ERAP2), an enzyme that process MHC-I ligands and preferentially trims N-terminal basic residues, i...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD014804 | Pride
Hla-b*40:02 peptidome Hla-b*27 Ankylosing spondylitis Erap2 
GenomicsGene expression of ERAP2 proficient and deficient patient-derived organoids post IFNg-stimulation
Gene expression of ERAP2 proficient and deficient patient-derived organoids post IFNg-stimulation
PRJNA1106384 | ENA
ProteomicsRedundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behçet’s Disease-Associated HLA-B*51 Peptidome
The endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 trim peptides to be loaded onto HLA molecules, including the main risk factor for Behçet’s disease HLA-B*51. ERAP1 is also a risk factor among HLA-B*51-positive individuals, whereas no association is known with ERAP2. This study addressed the...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD012348 | Pride
Hla-b*51 Erap1 Behçet’s disease Erap2 Peptidome 
TranscriptomicsGene expression of ERAP2 proficient and deficient patient-derived organoids post IFNg-stimulation
RNA-seq analysis of total RNA isolated from patient-derived organoids established from eight individuals. The organoids are genotyped with regards to rs2910686. The analysis aimed at characterizing the epithelial gene expression changes in ERAP2 proficient vs. ERAP2 deficient patient-derived organoi...
ORGANISM(S): Homo sapiens 
2024-08-16 | GSE266208 | GEO
GenomicsGenome-scale CRISPR-Cas9 knockout screening in primary renal tubule epithelial cells identifies ERAP2 as a potential target for cisplatin cytotoxicity
RNA-seq of HK-2 cells followed with ERAP2 inhibition and CDDP treatment
PRJEB88943 | ENA
TranscriptomicsERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via unfolded protein response signaling pathway
Pancreatic ductal adenocarcinoma (PDAC) is characterized by excessive desmoplasia and autophagy-dependent tumorigenic growth. Pancreatic stellate cells (PSCs) as a predominant stromal cell type play a critical role in PDAC biology. Autophagy facilitates PSC activation. However, the mechanism remains...
ORGANISM(S): Homo sapiens 
2022-04-30 | GSE172168 | GEO
UnknownEvolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2).
Not available
S-EPMC10721543 | biostudies-literature
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