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MetabolomicsA metabolic dependency of EBV can be targeted to hinder B cell transformation

Following infection of B cells, Epstein Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates NAD de novo bios...

2024-04-29 | MTBLS2243 | MetaboLights
GenomicsEpstein-Barr Virus Exploits Intrinsic B-Lymphocyte Transcription Programs to Achieve Immortal Cell Growth
Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) gene regulation through the cell RBPJ transcription factor (TF) is essential for conversion of resting B-lymphocytes (RBLs) into Lymphoblastoid Cell Lines (LCLs). ChIP-seq investigation of EBNA2 and RBPJ sites in LCL DNA found EBNA2 at 5151 and RBPJ at 10...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-29498 | biostudies-arrayexpress
ProteomicsLocus-specific proteomics identifies CHD4 and Polycomb PRC1 as novel repressors of Epstein-Barr virus lytic reactivation
The Epstein Barr virus (EBV) is a human gammaherpesvirus which infects over 90% of the global population and is associated with lymphoid and epithelioid cancers. After infection, EBV enters a latent state in B-cells where the viral genome persists as a nuclear episome maintained by expression of a s...
ORGANISM(S): Homo sapiens (Human) 
2026-02-11 | PXD068122 | Pride
Epigenetics Virus activation Locus specific proteomics Polycomb complex Epstein-barr virus Virus latency Nurd complex De-ubiquitinase 
TranscriptomicsEvidence of Dynamically Dysregulated Gene Expression Pathways in Hyper-responsive B Cells from African American Lupus Patients
In this report we applied standard and original methods of analysis of gene expression microarray data to delineate differences in the molecular pathways impacted by stimulation of Epstein-Barr virus (EBV) transformed B cells derived from patients with systemic lupus erythematosus (SLE) and normal u...
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37573 | biostudies-arrayexpress
UnknownExpression and methylation data from SLE patient and healthy control blood samples subdivided with respect to ARID3a levels.
Not available
S-EPMC5021782 | biostudies-literature
UnknownA proteome-wide analysis unveils a core Epstein-Barr virus antibody signature of classic Hodgkin lymphoma across ethnically diverse populations.
Not available
S-EPMC11326961 | biostudies-literature
UnknownEpstein-Barr virus, cytomegalovirus, and multiple sclerosis susceptibility: A multiethnic study.
Not available
S-EPMC5649756 | biostudies-literature
UnknownMultiple Sclerosis Is Rare in Epstein-Barr Virus-Seronegative Children with Central Nervous System Inflammatory Demyelination.
Not available
S-EPMC8244760 | biostudies-literature
UnknownThe case for targeting latent and lytic Epstein-Barr virus infection in multiple sclerosis.
Not available
S-EPMC12404723 | biostudies-literature
UnknownIdentifying Epstein-Barr virus peptide sequences associated with differential IgG antibody response.
Not available
S-EPMC8724419 | biostudies-literature
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