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TranscriptomicsEgr2-dependent expression in T cell anergy
T cell anergy is one of the mechanisms contributing to peripheral tolerance, particularly in the context of progressively growing tumors and in tolerogenic treatments promoting allograft acceptance. We recently reported that early growth response gene 2 (Egr2) is a critical transcription factor for...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46242 | biostudies-arrayexpress
GenomicsGenome-wide maps of EGR2 transcription factor binding sites in T cell anergy
We report the application of sequencing technology for mapping the EGR2 transcriptional program in T cell anergy Examination of Egr2 genomic binding sites in T cells following overnight treatment with immobilized anti-CD3 mAb (1ug/ml)
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46241 | biostudies-arrayexpress
TranscriptomicsGene expression in natural subyearling fall Chinook salmon in the Snake and Clearwater Rivers
We used gene expression accompanied by physical characteristics and gill Na+/K+-ATPase activity to analyze physiological differences associated with two life history variations of juvenile fall Chinook Salmon in the Snake River basin. Subyearlings originating in the Snake River typically migrate sea...
ORGANISM(S): Oncorhynchus tshawytscha 
2014-06-20 | E-GEOD-58670 | biostudies-arrayexpress
UnknownAntigen nature and complexity influence human antibody light chain usage and specificity.
Not available
S-EPMC4876604 | biostudies-literature
TranscriptomicsTranscription profiling of mouse kidney from FGF23, TG and WT mice
Fibroblast growth factor-23 (FGF23), a circulating protein produced in bone, causes renal inorganic phosphate (Pi) wasting by down-regulation of sodium phosphate co-transporter 2a (Npt2a). The mechanism behind this action is unknown. We have previously generated transgenic mice (TG) expressing human...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6979 | biostudies-arrayexpress
TranscriptomicsDown-regulation of BLIMP1-alpha by the EBV oncogene, LMP1, disrupts the plasma cell differentiation program and prevents viral replication in B cells
In this study, we have investigated the effect of BLIMP1α on gene expression, cell differentiation and pathogenesis in normal human GC B cells using a non-viral vector based system Gene expression was compared among BLIMP1α, LMP1-transfected and control vector-transfected GC B cells from two patient...
ORGANISM(S): Homo sapiens 
2011-07-26 | E-GEOD-27670 | biostudies-arrayexpress
TranscriptomicsTetracycline-treated Litomosoides sigmodontis vs. untreated control Litomosoides sigmodontis
The filarial nematodes Brugia malayi, Wuchereria bancrofti and Onchocerca volvulus cause elephantiasis, dermatitis and blindness, resulting in severe morbidity in developing countries. 1.3 billion people are at risk of infection. Targeting the essential Wolbachia endobacteria of filarial nematodes w...
ORGANISM(S): Litomosoides sigmodontis 
2010-04-07 | E-GEOD-20976 | biostudies-arrayexpress
TranscriptomicsDeep sequencing data for PAM-SCANR tested CRISPR-Cas systems
In this work, we analyzed recognized PAM sequences from four CRISPR-Cas systems: E. coli I-E, B. halodurans I-C, S. thermophilus CR1 II-A, and F. novicida V. Cells containing functional PAMs were sorted using FACS and subsequently sequenced. Ranking of recognized PAMs from a positive screen
ORGANISM(S): Francisella tularensis subsp. novicida 
2016-02-17 | E-GEOD-75718 | biostudies-arrayexpress
TranscriptomicsExpression data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines.
Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, subsequently resulting in a poor long-term prognosis. To model the onset of drug resista...
ORGANISM(S): Homo sapiens 
2009-04-17 | E-GEOD-15372 | biostudies-arrayexpress
TranscriptomicsIdentification of a B cell signature associated with renal transplant Tolerance in humans
In this study, investigators recruited the largest reported cohort of tolerant kidney transplant recipients who maintained their graft after ceasing to take their immunosuppression drug, and compared this cohort to subjects with stable allograft function while on immunosuppression and healthy non t...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-22229 | biostudies-arrayexpress
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