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MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
TranscriptomicsMthfd1 is a modifier of intestinal carcinogenesis
The metabolic pathways that underlie the association between folate deficiency and increased risk for colorectal cancer (CRC) remain unclear. We have studied the effect of C1THF synthase (encoded by the Mthfd1 gene) and dietary folate and choline on intestinal tumor development in Apcmin/+ mice and ...
ORGANISM(S): Mus musculus 
2010-03-20 | E-GEOD-15419 | biostudies-arrayexpress
ProteomicsTargeted mass spectrometry enables quantification of novel pharmacodynamic biomarkers of ATM kinase inhibitors
ATM is a serine/threonine protein kinase that is responsible for initiation of DNA repair of double-stranded breaks and is a therapeutic target in cancer. A lack of analytically robust and multiplexed assays has hampered mechanistic studies of action and determination of optimal, robust pharmacodyna...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD026103 | Pride
Human Lymphoblast Atm Phosphorylation 
TranscriptomicsSmall RNA sequencing of plasma extracellular vesicles from HIV/HCV coinfected patients
We have analyzed six different extracelular vesicles isolation protocols from plasma of patients coinfected with human immunodeficiency virus and hepatitis C virus (HIV/HCV). In addition, two different RNA isolation kit were used for each protocol, one phenol-based and another pehenol-free kit. Same...
ORGANISM(S): Homo sapiens 
2020-08-14 | E-MTAB-8246 | biostudies-arrayexpress
TranscriptomicsGenetically-driven target tissue over-expression of CD40: A novel mechanism in autoimmune disease
The CD40 gene, an important immune regulatory gene, is also expressed and functional on non-myeloid derived cells, many of which are targets for tissue specific autoimmune diseases, including d thyroid follicular cells in Graves’ disease (GD). Whether target tissue CD40 expression plays a role in au...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-39081 | biostudies-arrayexpress
TranscriptomicsLeishmania major promastigote ChIP-chip: TBP, SNAP50, acetylH3
The goal of this study is to identify likely sites of polycistronic transcription initiation in a kinetoplastid parasite. Peaks in histone H3 acetylations were found to mark these likely sites, with TBP and SNAP50 enriched upstream of these acetylation peaks. Acetylation peaks are greater in rapid...
ORGANISM(S): Leishmania major 
2010-05-16 | E-GEOD-13415 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human Hela cells grown under serum starved condtions to identify new targets genes for ETS-domain transcription factor Elk-1
Chromatin immunoprecipitation coupled with microarray analysis (ChIP-chip) was carried out to identify new target genes for ETS-domain transcription factor Elk-1. Experiment was done in Hela cells under serum starved conditions.
ORGANISM(S): Homo sapiens 
2009-08-11 | E-MEXP-1527 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human HeLa cells grown under serum starved conditions to identify new target genes for ETS-domain transcription factor Elk-1
Chromatin immunoprecipitation coupled with microarray analysis (ChIP-chip) was carried out to identify new target genes for ETS-domain transcription factor Elk-1. Experiment was done in Hela cells under serum starved conditions.
ORGANISM(S): Homo sapiens 
2009-08-11 | E-MEXP-2084 | biostudies-arrayexpress
MetabolomicsSimultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics
Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its biotransformation products as part of the metabolomics analysis provides an opportunity to simultaneously gain deep insights int...
2023-07-03 | MTBLS2746 | MetaboLights
TranscriptomicsDNA methylation array of human purified intestinal epithelial samples and organoids from paediatric and foetal small and large intestine
Human intestinal epithelial organoids (IEO) culture models are rapidly emerging as novel experimental tools to investigate fundamental aspects of intestinal epithelial (patho)physiology. Cellular source and culture protocols vary between different IEO models and reliable markers for their characteri...
ORGANISM(S): Homo sapiens 
2017-10-31 | E-MTAB-4957 | biostudies-arrayexpress
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