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MetabolomicsDifferentiation Defect Repositions Sebaceous Glands as Instigators in the Early Pathogenesis of Hidradenitis Suppurativa

The role of sebaceous glands (SGs) in the early pathogenesis of hidradenitis suppurativa (HS) is undefined, with unclear causal relationship to inflammatory sequelae. The aim of this study was to determine whether SG aberrations constitute a primary pathogenic driver in early HS and elucidate the...

2025-12-28 | MTBLS13578 | MetaboLights
TranscriptomicsInterferon lambda restricts West Nile virus neuroinvasion by enhancing integrity of the blood-brain barrier
Although type III interferons (IFN), also known as IFN-λ or IL28/IL-29, restrict infection by several viruses, their mechanism of inhibitory action has remained uncertain. We used recombinant IFN-λ and mice lacking the IFN-λ receptor (IFNLR1) to evaluate the effect of IFN-λ on infection with West Ni...
ORGANISM(S): Mus musculus 
2015-01-08 | E-GEOD-64735 | biostudies-arrayexpress
TranscriptomicsMicroarray data from control and pericyte-deficient mouse brain microvascular transcriptomes
The blood-brain barrier (BBB) consists of specific physical barriers, enzymes and transporters, which together maintain the necessary extracellular environment of the central nervous system (CNS). The main physical barrier is found in the CNS endothelial cell, and depends on continuous complexes of ...
ORGANISM(S): Mus musculus 
2010-10-21 | E-GEOD-15892 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skins of embryos lacking Grainyhead-like epithelial transactivator (Get-1)
Defective permeability barrier is an important feature of many skin diseases and causes mortality in premature infants. To investigate the control of barrier formation, we characterized the epidermally expressed Grainyhead-like epithelial transactivator (Get-1)/Grhl3, a conserved mammalian homologue...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7381 | biostudies-arrayexpress
UnknownCeliac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells.
Not available
S-EPMC6888450 | biostudies-literature
TranscriptomicsExpression changes between loricrin knockout and wildtype P0
The loss of loricrin, a major component of the cornified envelope, results in a delay of epidermal barrier formation. Therefore, the living layers of the epidermis are aberrantly exposed to late-stage amniotic fluid, which may serve as the signal to upregulate genes that functionally compensate for ...
ORGANISM(S): Mus musculus 
2013-06-28 | E-GEOD-41742 | biostudies-arrayexpress
UnknownLipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3.
Not available
S-EPMC2064601 | biostudies-literature
ProteomicsBacterial Pyocyanin Inducible KRT6A Accelerates Closure of Epithelial Defect Under Conditions of Mitochondrial Dysfunction
Repair of epithelial defect is complicated by infection and related metabolites. Pyocyanin is one such metabolite that is secreted during Pseudomonas aeruginosa infection. Keratinocyte migration is required for the closure of skin epithelial defects. The current work sought to understand pyocyanin-k...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-12 | MSV000091054 | MassIVE
UnknownLong Noncoding RNA FBXL19-AS1-Mediated Ulcerative Colitis-Associated Intestinal Epithelial Barrier Defect.
Not available
S-EPMC9478015 | biostudies-literature
UnknownGrowth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58).
Not available
S-EPMC2844178 | biostudies-literature
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