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ProteomicsExploring the structural landscape of DNA maintenance proteins
Evolutionary annotation of genome maintenance (GM) proteins has conventionally been established by remote relationships within protein sequence databases. However, often no significant relationship can be established. Highly sensitive approaches to attain remote homologies based on iterative profile...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD043273 | Pride
Dna damage repair Protein folding Lc-ms/ms 
ProteomicsU2OS LC MSMS upon siRNA-eIF4A3 or 5nM ActD treatment.
Proteome analysis in U2OS cells treated with siRNA against eIf4A3 or 5nM Actinomycin D.
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD016005 | Pride
U2os lc msms upon sirna-eif4a3 or 5nm actd treatment. 
TranscriptomicsNanopore RNA-seq of human cell lines treated with or without nicotinamide adenine dinucleotide (NAD+)
Investigation of transcriptome changes in four human cell lines (BJ, BJ-5ta, U2OS and HeLa) after treatment for 24 hours with nicotinamide adenine dinucleotide (NAD+). Cells were untreated as the control condition. Nanopore sequencing of cDNA was performed after library preparation with the ONT SQK...
ORGANISM(S): Homo sapiens 
2023-09-20 | E-MTAB-13187 | biostudies-arrayexpress
TranscriptomicsNanopore RNA-seq of human osteosarcoma cell line U2OS treated with siRNA against MDC1, PLRG1, or control siRNA with or without pladienolide B
The purpose was to investigate transcript and splicing changes in U2OS cells following siRNA-mediated depletion of MDC1 and PLRG1 or treatment with the splicing inhibitor pladienolide B. Cells were treated with control siRNA as control condition. Nanopore sequencing of cDNA was performed after libra...
ORGANISM(S): Homo sapiens 
2023-01-11 | E-MTAB-12497 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of JAK2wt and JAK2V617F+ iPSCs and iPSC-derived CD34+ progenitor-enriched cultures, either inflammatory cytokines treated or untreated.
PV-patient specific and control healthy individual-derived iPSCs were upon differentiation for 9 days into CD34+ hematopoietic progenitors treated with IFNγ, TNFα and TGFβ1 or untreated and used for transcriptome analysis. This dataset shows presence of cell-autonomous and strong non-cell autonomous...
ORGANISM(S): Homo sapiens 
2020-12-03 | E-MTAB-7693 | biostudies-arrayexpress
TranscriptomicsDNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-induced Leukemogenesis in vivo
Activation of the MLL-ENL-ERtm oncogene initiates aberrant proliferation of myeloid progenitors. Here, we show induction of a fail-safe mechanism mediated by the DNA damage response (DDR) machinery that results in activation of the ATR/ATM-Chk1/Chk2-p53/p21 checkpoint and cellular senescence at earl...
ORGANISM(S): Mus musculus 
2012-04-21 | E-GEOD-35038 | biostudies-arrayexpress
UnknownHuman Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities
Not available
S-JCBD-200812138 | bioimages
UnknownThe chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
Not available
S-JCBD-200912135 | bioimages
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