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TranscriptomicsDevelopmental timecourse of C. elegans small RNAs with 5p monophosphates
These datasets profile the expression of small RNAs with 5p monophosphates and 3p hydroxyls (including miRNAs, 21U-RNAs) across C. elegans development and in dauer, glp-4 mutant, and mixed-stage wt worms. These datasets were prepared in the David P. Bartel laboratory using T4 RNA ligase Rnl2(1-249)....
ORGANISM(S): Caenorhabditis elegans 
2008-06-15 | E-GEOD-11734 | biostudies-arrayexpress
ProteomicsThe Parkinson's disease protein alpha-synuclein is a direct modulator of Processing-bodies and mRNA stability
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR,Carr SA, de Jager P, Myers CL, Lindquist S, Greenmyre TJ, Bartel DP, Feany MB, Sunyaev S, Chung CY and Khurana V. Alp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089026 | MassIVE
GenomicsConserved Function of lincRNAs in Vertebrate Embryonic Development Despite Rapid Sequence Evolution
Thousands of large intervening non-coding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-site mapping and RNA-Seq data, to identify more than 550 distinct lincRNAs in zebrafish. Although thes...
ORGANISM(S): Danio rerio 
2011-12-22 | E-GEOD-32880 | biostudies-arrayexpress
TranscriptomicsSmall RNAs from the lycopod Selaginella moellendorffii
The small RNAs of Selaginella moellendorffii were sampled by direct pyrosequencing (454 Life Sciences). These data represent microRNAs, siRNAs, and other expressed small RNAs of ~18-~28 nts. in length. Keywords: Small RNA sequencing - high throughput One sample of above-ground tissues of greenhouse...
ORGANISM(S): Selaginella moellendorffii 
2007-06-29 | E-GEOD-7320 | biostudies-arrayexpress
TranscriptomicsExtensive alternative polyadenylation during zebrafish development
The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3' untranslated regions (3'UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling by sequencing (3P-Seq) to map poly(A) sites at eight developmental stages an...
ORGANISM(S): Danio rerio 
2012-06-17 | E-GEOD-37453 | biostudies-arrayexpress
TranscriptomicsDegradome sequencing from S. castellii
The RNA-induced silencing complex, comprising Argonaute and guide RNA, mediates RNA interference. Here we report the 3.2 M-CM-^E crystal structure of Kluyveromyces Argonaute (KpAGO) fortuitously complexed with guide RNA originating from small-RNA duplexes autonomously loaded by recombinant KpAGO. De...
ORGANISM(S): Naumovozyma castellii 
2012-05-14 | E-GEOD-37723 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression during cell cycle arrest
The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or down-regulated in many types of cancers. Here we report the reciprocal relationship - that of the cell cycle controlling the miR-16 family...
ORGANISM(S): Mus musculus 
2011-09-15 | E-GEOD-31225 | biostudies-arrayexpress
TranscriptomicsmiRNA expression of human cancer and mouse cell lines
miRNA expression profile Keywords: small RNA profiling by high throughput sequencing The small RNA fraction (18-30nt) was cloned and sequenced from total RNA of each cell line
ORGANISM(S): Homo sapiens 
2009-08-24 | E-GEOD-16579 | biostudies-arrayexpress
TranscriptomicsMammalian microRNAs: Experimental evaluation of novel and previously annotated genes
MicroRNAs (miRNAs) are small regulatory RNAs that derive from distinctive hairpin transcripts. To learn more about the miRNAs of mammals, we sequenced 60 million small RNAs from mouse brain, ovary, testes, embryonic stem cells, three embryonic stages, and whole newborns. Analysis of these sequences ...
ORGANISM(S): Homo sapiens 
2010-04-26 | E-GEOD-20384 | biostudies-arrayexpress
TranscriptomicsBacteria-derived small RNAs that co-purify with KpAGO
The RNA-induced silencing complex, comprising Argonaute and guide RNA, mediates RNA interference. Here we report the 3.2 Å crystal structure of Kluyveromyces Argonaute (KpAGO) fortuitously complexed with guide RNA originating from small-RNA duplexes autonomously loaded by recombinant KpAGO. Despite ...
ORGANISM(S): Vanderwaltozyma polyspora 
2012-05-14 | E-GEOD-37724 | biostudies-arrayexpress
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