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ProteomicsStreamlined identification of permissive non-canonical amino acid incorporation sites in mammalian cell lines with an expanded genetic code
The genetic code of mammalian cells can be expanded to allow the incorporation of non-canonical amino acids (ncAAs) by suppressing in-frame amber stop codons (UAG) with an orthogonal pyrrolysyl-tRNA synthetase (PylRS)/tRNAPylCUA (PylT) pair. However, the feasibility of this approach is substantially...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-02-23 | PXD019815 | Pride
Genetic code expansion Unnatural amino acids Non-canonical amino acids Amber suppression 
ProteomicsChIP-MS of DPPA3/STELLA in mouse embryonic stem cells
Genome-wide DNA demethylation is a unique feature of mammalian development and naïve pluripotent stem cells. So far, it was unclear how mammals specifically achieve global DNA hypomethylation, given the high conservation of the DNA (de-)methylation machinery among vertebrates. We found that DNA deme...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-12 | PXD019794 | Pride
Epigenetics Dna methylation Escs Chip-ms 
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