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GenomicsLong range spreading of dosage compensation in Drosophila captures transcribed autosomal genes inserted on X
Dosage compensation in D. melanogaster males is achieved via targeting of the MSL complex to X chromosomal genes. This is proposed to involve initial sequence-specific recognition of the X at ~150-300 chromatin entry sites, and subsequent spreading to nearby active genes. Here we test a model in whi...
ORGANISM(S): Drosophila melanogaster 
2009-08-20 | E-GEOD-17729 | biostudies-arrayexpress
ProteomicsMouse ameloblasts Bcl9 interactors
Bcl9 and Bcl9l (Bcl9l) are commonly thought as beta-catenin-dependent Wnt signaling transcriptional activators. We find however that, in the enamel-producin ameloblasts cells, Bcl9/9l are localiyed in the cytoplasm toward to apical secretory membrane. We performed pull down followed by mass spectrom...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-13 | PXD005449 | Pride
Enamel Ameloblasts Pygo Bcl9 
TranscriptomicsBCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer
Canonical Wnt signaling output is mediated by β-catenin, which interacts with LEF/TCF transcription factors and recruits a general transcriptional activation complex to its C-terminus. Its N-terminus binds BCL9/9L proteins, which bind co-activators that in mammals contribute to fine-tuning the tran...
ORGANISM(S): Mus musculus 
2015-11-08 | E-GEOD-60837 | biostudies-arrayexpress
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