Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Primary Cell, Epithelial Cell
DISEASE(S): Disease Free
SUBMITTER: Claudio Cantù
LAB HEAD: Claudio Cantù - lab of Konrad Basler
PROVIDER: PXD005449 | Pride | 2017-02-13
REPOSITORIES: Pride
Cantù Claudio C Pagella Pierfrancesco P Shajiei Tania D TD Zimmerli Dario D Valenta Tomas T Hausmann George G Basler Konrad K Mitsiadis Thimios A TA
Science signaling 20170207 465
Wnt-stimulated β-catenin transcriptional regulation is necessary for the development of most organs, including teeth. Bcl9 and Bcl9l are tissue-specific transcriptional cofactors that cooperate with β-catenin. In the nucleus, Bcl9 and Bcl9l simultaneously bind β-catenin and the transcriptional activator Pygo2 to promote the transcription of a subset of Wnt target genes. We showed that Bcl9 and Bcl9l function in the cytoplasm during tooth enamel formation in a manner that is independent of Wnt-st ...[more]